Mouse anti-Human, Mouse HSD17B10 Monoclonal Antibody | anti-HSD17B10 antibody

HSD17B10 Monoclonal Antibody

Cat. Num. AAA2542252

• Gene Names: HSD17B10; ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; HSD10MD; 17b-HSD10; DUPXp11.22
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Caprylic acid/ammonium sulfate precipitation
• Synonyms: HSD17B10; Monoclonal Antibody; HSD17B10 Monoclonal Antibody; 17 beta hydroxysteroid dehydrogenase 10; 17 beta hydroxysteroid dehydrogenase type 10; 17-beta-HSD 10; 17-beta-hydroxysteroid dehydrogenase 10; 17b HSD10; 3 hydroxy 2 methylbutyryl CoA dehydrogenase; 3 hydroxyacyl CoA dehydrogenase type 2; 3 hydroxyacyl CoA dehydrogenase type II; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; AB binding alcohol dehydrogenase; ABAD; Ads9; Amyloid beta binding polypeptide; Amyloid beta peptide binding alcohol dehydrogenase; Amyloid beta peptide binding protein; CAMR; DUPXp11.22; Endoplasmic Reticulum Amyloid Binding Protein; Endoplasmic reticulum associated amyloid beta peptide binding protein; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ER associated amyloid beta-binding protein; ERAB; HADH 2; HADH2; HCD 2; HCD2; Hsd17b10; Hydroxyacyl CoA Dehydrogenase type II; Hydroxyacyl Coenzyme A dehydrogenase type II; Hydroxysteroid (17 beta) dehydrogenase 10; Mental retardation X linked syndromic 11; MHBD; Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; MRPP2; MRX17; SCHAD; SDR5C1; Short chain dehydrogenase/reductase family 5C member 1; Short chain L 3 hydroxyacyl CoA dehydrogenase type 2; Short chain type dehydrogenase/reductase XH98G2; Short-chain type dehydrogenase/reductase XH98G2; Type 10 17b HSD; Type 10 17beta hydroxysteroid dehydrogenase; Type II HADH; XH98G2; anti-HSD17B10 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 9546
• Purity/Purification: Caprylic acid/ammonium sulfate precipitation
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 252

• Applicable Applications for anti-HSD17B10 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-1:10000
• Immunogen: Fusion protein of ERAB
• Buffer: PBS with 0.1% sodium azide, 50% glycerol, PH7.3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of ROS1728 cells using ERAB Monoclonal Antibody at dilution of 1:2000)

Related Product Information for anti-HSD17B10 antibody

HSD17B10 (3-hydroxyacyl-CoA dehydrogenase type-2) is a multifunctional mitochondrial enzyme that acts on a wide spectrum of substrates, including neuroactive steroids, alcohols, leucine, and fatty acids, with a preference for short-chain methyl-branched acyl-CoAs.It has 2 isoforms produced by alternative splicing.Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) and mental retardation syndromic X-linked type 10 (MRXS10).

Product Categories/Family for anti-HSD17B10 antibody

Cancer; Metabolism; Neuroscience; Tags & Cell Markers

NCBI and Uniprot Product Information

• NCBI GI #: 83715985
• NCBI GeneID: 3028
• NCBI Accession #: NP_001032900.1
• NCBI GenBank Nucleotide #: NM_001037811.2
• UniProt Accession #: Q99714; Q5H927; Q6IBS9; Q8TCV9; Q96HD5
• Molecular Weight: Calculated: 26kDa; Observed: 27kDa
• NCBI Official Full Name: 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 2
• NCBI Official Synonym Full Names: hydroxysteroid 17-beta dehydrogenase 10
• NCBI Official Symbol: HSD17B10
• NCBI Official Synonym Symbols: ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; HSD10MD; 17b-HSD10; DUPXp11.22
• NCBI Protein Information: 3-hydroxyacyl-CoA dehydrogenase type-2
• UniProt Protein Name: 3-hydroxyacyl-CoA dehydrogenase type-2
• Protein Family: 3-hydroxyacyl-CoA dehydrogenase
• UniProt Gene Name: HSD17B10
• UniProt Synonym Gene Names: ERAB; HADH2; MRPP2; SCHAD; SDR5C1; XH98G2; Mitochondrial RNase P protein 2

NCBI Description

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Uniprot Description

Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426).