Rabbit anti-Human PSRC1 Polyclonal Antibody | anti-PSRC1 antibody

PSRC1 (Proline/serine-rich Coiled-coil Protein 1, DDA3, FP3214) (FITC)

Cat. Num. AAA6391245

• Gene Names: PSRC1; DDA3; FP3214
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PSRC1; Polyclonal Antibody; PSRC1 (Proline/serine-rich Coiled-coil Protein 1; DDA3; FP3214) (FITC); MGC1780; RP11-297O4.2; anti-PSRC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PSRC1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 333

• Applicable Applications for anti-PSRC1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PSRC1, aa1-333 (NP_116025.1).
• Immunogen Sequence: MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PSRC1 expression in transfected 293T cell line by PSRC1 polyclonal antibody. Lane 1: PSRC1 transfected lysate (35.6kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-PSRC1 antibody

Antibodies; CCDC (Coiled-coil Domain-containing)

NCBI and Uniprot Product Information

• NCBI GI #: 14249168
• NCBI GeneID: 84722
• NCBI Accession #: NP_116025.1
• NCBI GenBank Nucleotide #: NM_032636
• UniProt Accession #: Q6PGN9
• NCBI Official Full Name: proline/serine-rich coiled-coil protein 1 isoform a
• NCBI Official Synonym Full Names: proline and serine rich coiled-coil 1
• NCBI Official Symbol: PSRC1
• NCBI Official Synonym Symbols: DDA3; FP3214
• NCBI Protein Information: proline/serine-rich coiled-coil protein 1
• UniProt Protein Name: Proline/serine-rich coiled-coil protein 1
• Protein Family: Proline/serine-rich coiled-coil protein
• UniProt Gene Name: PSRC1
• UniProt Synonym Gene Names: DDA3

NCBI Description

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Uniprot Description

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.