Mouse HLA-DR Monoclonal Antibody | anti-HLA-DR antibody

Anti-HLA-DR PerCP-Cyanine5.5

Cat. Num. AAA1800855

• Gene Names: HLA-DQB1; IDDM1; CELIAC1; HLA-DQB
• Reactivity: Dog, Non-human primates, Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with tandem dye PerCP-Cyanine5.5 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: HLA-DR; Monoclonal Antibody; Anti-HLA-DR PerCP-Cyanine5.5; anti-HLA-DR antibody

• Host: Mouse
• Reactivity: Dog, Non-human primates, Human
• Clonality: Monoclonal
• Isotype: IgG2a kappa
• Clone Number: L243
• Specificity: The mouse monoclonal antibody L243 recognizes specifically an extracellular epitope on HLA-DR molecules, both peptide-loaded and empty.
• Purity/Purification: The purified antibody is conjugated with tandem dye PerCP-Cyanine5.5 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 42

• Applicable Applications for anti-HLA-DR antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Immunogen: Human B lymphocytes
• Conjugation: PerCP-Cyanine5.5
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of HLA-DR in human peripheral blood with anti-HLA-DR (L243) PerCP-Cy5.5.)

Related Product Information for anti-HLA-DR antibody

HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.

NCBI and Uniprot Product Information

• NCBI GI #: 642238
• NCBI GeneID: 3119
• NCBI Official Full Name: HLA-DR, partial
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DQ beta 1
• NCBI Official Symbol: HLA-DQB1
• NCBI Official Synonym Symbols: IDDM1; CELIAC1; HLA-DQB
• NCBI Protein Information: HLA class II histocompatibility antigen, DQ beta 1 chain

NCBI Description

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]