Mouse anti-Human HIVEP2 Monoclonal Antibody | anti-HIVEP2 antibody

Mouse monoclonal antibody Anti-Human HIVEP2

Cat. Num. AAA120441

• Gene Names: HIVEP2; SHN2; ZAS2; MBP-2; MIBP1; ZNF40B; HIV-EP2
• Reactivity: Human
• Applications: Dot Blot
• Synonyms: HIVEP2; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human HIVEP2; Homo sapiens human immunodeficiency virus type I enhancer binding protein 2 (HIVEP2); mRNA.; MBP-2; MIBP1; HIV-EP2; anti-HIVEP2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2418C2a
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 9732

• Applicable Applications for anti-HIVEP2 antibody: Dot Blot (DB)
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.

Quality Control

(Left: Western blot analysis of immunized recombinant protein, using anti-HIVEP2 monoclonal antibody.)

Related Product Information for anti-HIVEP2 antibody

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 110347462
• NCBI GeneID: 3097
• NCBI Accession #: NP_006725.3
• NCBI GenBank Nucleotide #: NM_006734
• Molecular Weight: 269,053 Da
• NCBI Official Full Name: Homo sapiens human immunodeficiency virus type I enhancer binding protein 2 (HIVEP2), mRNA
• NCBI Official Synonym Full Names: human immunodeficiency virus type I enhancer binding protein 2
• NCBI Official Symbol: HIVEP2
• NCBI Official Synonym Symbols: SHN2; ZAS2; MBP-2; MIBP1; ZNF40B; HIV-EP2
• NCBI Protein Information: transcription factor HIVEP2; MHC binding protein-2; MHC-binding protein 2; Schnurri-2; c-myc intron binding protein 1; human immunodeficiency virus type I enhancer-binding protein 2
• UniProt Protein Name: Transcription factor HIVEP2
• Protein Family: Human immunodeficiency virus type I enhancer-binding protein
• UniProt Gene Name: HIVEP2
• UniProt Entry Name: ZEP2_HUMAN

NCBI Description

This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

Uniprot Description

HIVEP2: This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon- beta genes. It may act in T-cell activation.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: nucleoplasm

Molecular Function: DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent