Mouse Heat Shock Protein 90, alpha Monoclonal Antibody | anti-HSP90AB1 antibody

Heat Shock Protein 90, alpha (HSP90a)

Cat. Num. AAA608988

• Gene Names: HSP90AB1; HSP90
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Heat Shock Protein 90; alpha; Monoclonal Antibody; alpha (HSP90a); Anti -Heat Shock Protein 90; anti-HSP90AB1 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1, Kappa
• Clone Number: 10F737
• Specificity: Recognizes human hsp90alpha. Species Crossreactivity: rat.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.

• Applicable Applications for anti-HSP90AB1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.; Dilution: Western Blot: 1:2000
• Immunogen: Human Hsp90alpha.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-HSP90AB1 antibody

HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms a and b, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities,

Product Categories/Family for anti-HSP90AB1 antibody

Antibodies; Abs to Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 126352614
• NCBI GeneID: 100034150
• NCBI Accession #: NP_001075407.1
• NCBI GenBank Nucleotide #: NM_001081938.1
• UniProt Accession #: Q9GKX8; Q6TXV3
• Molecular Weight: 83,237 Da
• NCBI Official Full Name: heat shock protein HSP 90-beta
• NCBI Official Symbol: HSP90AB1
• NCBI Official Synonym Symbols: HSP90
• NCBI Protein Information: heat shock protein HSP 90-beta; heat shock protein 90; Heat shock protein HSP 90-beta-like protein
• UniProt Protein Name: Heat shock protein HSP 90-beta
• Protein Family: Heat shock protein
• UniProt Gene Name: HSP90AB1
• UniProt Synonym Gene Names: HSPCB
• UniProt Entry Name: HS90B_HORSE

Uniprot Description

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function

By similarity.

Subunit structure: Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4

By similarity.

Subcellular location: Cytoplasm

By similarity. Melanosome

By similarity.

Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins

By similarity.

Post-translational modification: ISGylated

By similarity.Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro)

By similarity.S-nitrosylated; negatively regulates the ATPase activity

By similarity.

Sequence similarities: Belongs to the heat shock protein 90 family.