Rabbit anti-Human GranzymeB/GZMB  Monoclonal Antibody | anti-GZMB  antibody

Rabbit anti Human GranzymeB/GZMB  Monoclonal Antibody

Cat. Num. AAA2543948

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Synonyms: GranzymeB/GZMB ; Monoclonal Antibody; Rabbit anti Human GranzymeB/GZMB Monoclonal Antibody; anti-GZMB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG

• Applicable Applications for anti-GZMB antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human Granzyme B. The detection limit for Human Granzyme B is approximately 0.00975 ng/well.; IHC-P: 0.5-5 mug/mL
• Immunogen: Recombinant Human Granzyme B protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-GZMB  antibody

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.