Rabbit anti-Human Glyoxalase II/HAGH Monoclonal Antibody | anti-HAGH antibody
Recombinant Anti-Glyoxalase II/HAGH Antibody, Rabbit Monoclonal
Gene Names
HAGH; GLO2; GLX2; GLXII; HAGH1
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
Glyoxalase II/HAGH; Monoclonal Antibody; Recombinant Anti-Glyoxalase II/HAGH Antibody; Rabbit Monoclonal; HAGH Antibody; Rabbit MAb; hydroxyacylglutathione hydrolase; Anti-GLO2 Antibody; Anti-GLX2 Antibody; Anti-GLXII Antibody; Anti-HAGH1 Antibody; anti-HAGH antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
002
Specificity
Human HAGH
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-HAGH antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human HAGH protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human HAGH (rh HAGH).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-HAGH antibody
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathione Hydrolase Deficiency. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Metabolism. The human and rodent forms of glyoxalase II (HAGH) can readily be separated by starch gel electrophoretic procedures.
References
Mulley JC, et al. (1987). New regional localisations for HAGH and PGP on human chromosome 16. Hum Genet 74 (4): 423-4.Rulli A, et al. (2001). Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res. Treat. 66 (1): 67-72.Cordell PA, et al. (2004). The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 279 (27): 28653-61.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,455 Da
NCBI Official Full Name
hydroxyacylglutathione hydrolase, mitochondrial isoform 2
NCBI Official Synonym Full Names
hydroxyacylglutathione hydrolase
NCBI Official Symbol
HAGH
NCBI Official Synonym Symbols
GLO2; GLX2; GLXII; HAGH1
NCBI Protein Information
hydroxyacylglutathione hydrolase, mitochondrial; glx II; glyoxalase II; hydroxyacylglutathione hydroxylase
UniProt Protein Name
Hydroxyacylglutathione hydrolase, mitochondrial
UniProt Gene Name
HAGH
UniProt Synonym Gene Names
GLO2; HAGH1; Glx II
UniProt Entry Name
GLO2_HUMAN
NCBI Description
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Description
HAGH: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 3.1.2.6; Carbohydrate Metabolism - pyruvate; Hydrolase
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: mitochondrial matrix; cytoplasm
Molecular Function: hydroxyacylglutathione hydrolase activity; zinc ion binding
Biological Process: glutathione biosynthetic process
Disease: Hydroxyacyl Glutathione Hydrolase Deficiency
Research Articles on HAGH
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Product Notes
The HAGH hagh (Catalog #AAA8106213) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-Glyoxalase II/HAGH Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Glyoxalase II/HAGH can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the HAGH hagh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glyoxalase II/HAGH, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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