Mouse anti-Human Glycine Receptor Subunit alpha 1 Monoclonal Antibody | anti-GLRA1 antibody

Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit, Glycine receptor strychnine-binding subunit, GLRA1)

Cat. Num. AAA605777

• Gene Names: GLRA1; STHE; MGC138878; MGC138879
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Glycine Receptor Subunit alpha 1; Monoclonal Antibody; Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit; Glycine receptor strychnine-binding subunit; GLRA1); Anti -Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit; anti-GLRA1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G364
• Specificity: Recognizes human Glycine Receptor Subunit alpha 1.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-GLRA1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and direct ELISA.
• Immunogen: Partial recombinant protein of human glycine receptor subunit alpha-1 (aa 121-221) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot detection of recombinant GST tagged human glycine receptor subunit alpha-1 using MBS605777.)

Related Product Information for anti-GLRA1 antibody

Glycine receptor is a neurotransmitter-gated ion channel. When bound to its ligand, glycine, chloride conductance is increased and consequently inhibits neuronal firing. It is a pentameric receptor composed of alpha and beta subunits and localises to the cell junction, synapse and postsynaptic cell membrane. Defects in GLRA1 cause startle disease (STHE) which is also known as hereditary hyperekplexia or congenital stiff-person syndrome.

Product Categories/Family for anti-GLRA1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 225903367
• NCBI GeneID: 2741
• NCBI Accession #: NP_001139512.1
• NCBI GenBank Nucleotide #: NM_001146040.1
• UniProt Accession #: P23415; Q14C77; Q6DJV9; B2R6T3; Q14C71; Q6LC95
• Molecular Weight: 52,624 Da
• NCBI Official Full Name: glycine receptor subunit alpha-1 isoform 1
• NCBI Official Synonym Full Names: glycine receptor, alpha 1
• NCBI Official Symbol: GLRA1
• NCBI Official Synonym Symbols: STHE; MGC138878; MGC138879
• NCBI Protein Information: glycine receptor subunit alpha-1; OTTHUMP00000160616; OTTHUMP00000224176; glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit
• UniProt Protein Name: Glycine receptor subunit alpha-1
• Protein Family: Glycine receptor
• UniProt Gene Name: GLRA1
• UniProt Entry Name: GLRA1_HUMAN

NCBI Description

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Uniprot Description

GLRA1: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1). A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; external side of plasma membrane

Molecular Function: protein binding; transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; taurine binding

Biological Process: regulation of action potential; startle response; synaptic transmission, glycinergic; righting reflex; acrosome reaction; chloride transport; neurological control of breathing; adult walking behavior; neuromuscular process controlling posture; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; visual perception; muscle contraction; negative regulation of transmission of nerve impulse; neuropeptide signaling pathway; ion transport; transmembrane transport

Disease: Hyperekplexia, Hereditary 1