Mouse Glutathione Peroxidase 3 Monoclonal Antibody | anti-GPX3 antibody

Glutathione Peroxidase 3 antibody

• Gene Names: GPX3; GPx-P; GSHPx-3; GSHPx-P
• Applications: ELISA, Immunoprecipitation
• Purity: Glutathione Peroxidase 3 antibody was purified by ammonium sulfate precipitation
• Synonyms: Glutathione Peroxidase 3; Monoclonal Antibody; Glutathione Peroxidase 3 antibody; Monoclonal Glutathione Peroxidase 3; Anti-Glutathione Peroxidase 3; GPX3; glutathione peroxidase 3 (plasma); BOS_8292; EGPx; extracellular glutathione peroxidase; extracellular GPx; glutathione peroxidase 3; GPx; GPx-3; Gpxp; GPx-P; GSHPx-3; GSHPx-P; plasma glutathione peroxidase; plasma GPx; anti-GPX3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Clone Number: 55A
• Purity/Purification: Glutathione Peroxidase 3 antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 226

• Applicable Applications for anti-GPX3 antibody: ELISA (EIA), Immunoprecipitation (IP)
• Application Notes: IP: 1 ul
• Biological Significance: Glutathione Peroxidase 3 (GPX3), also known as Plasma Glutathione Peroxidase, is a 226 amino acid member of the glutathione peroxidase antioxidant enzyme family. The Glutathione Peroxidase family protects cell surfaces, extracellular fluid components, and enzymes from oxidative stress by catalysing the reduction of hydrogen peroxide, lipid peroxides, and organic hydroperoxide using reduced glutathione.
• Cross-Reactivity: Human
• Immunogen: Glutathione Peroxidase 3 antibody was raised in Mouse using a recombinant human protein purified from E Coli as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

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Related Product Information for anti-GPX3 antibody

Mouse monoclonal Glutathione Peroxidase 3 antibody

Product Categories/Family for anti-GPX3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 6006001
• NCBI GeneID: 2878
• NCBI Accession #: NP_002075.2
• NCBI GenBank Nucleotide #: NM_002084.3
• UniProt Accession #: P22352; O43787; Q86W78; Q9NZ74; Q9UEL1
• Molecular Weight: 25,552 Da
• NCBI Official Full Name: glutathione peroxidase 3
• NCBI Official Synonym Full Names: glutathione peroxidase 3
• NCBI Official Symbol: GPX3
• NCBI Official Synonym Symbols: GPx-P; GSHPx-3; GSHPx-P
• NCBI Protein Information: glutathione peroxidase 3
• UniProt Protein Name: Glutathione peroxidase 3
• Protein Family: Glutathione peroxidase
• UniProt Gene Name: GPX3
• UniProt Synonym Gene Names: GPXP; GPx-3; GSHPx-3; GPx-P; GSHPx-P
• UniProt Entry Name: GPX3_HUMAN

NCBI Description

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Uniprot Description

GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family.

Protein type: Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid; EC 1.11.1.9; Secreted, signal peptide; Secreted; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular space; extracellular region

Molecular Function: selenium binding; glutathione peroxidase activity; transcription factor binding

Biological Process: response to reactive oxygen species; response to lipid hydroperoxide; hydrogen peroxide catabolic process; protein homotetramerization