Rat anti-Mouse GITR / Tnfrsf18 Monoclonal Antibody | anti-Tnfrsf18 antibody
GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody
Gene Names
Tnfrsf18; AITR; Gitr
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunofluorescence
Synonyms
GITR / Tnfrsf18; Monoclonal Antibody; GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody; Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18; anti-Tnfrsf18 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2b, lambda
Clone Number
DTA-1
Specificity
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAP's and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
228
Applicable Applications for anti-Tnfrsf18 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes
Flow Cytometry (0.5-1ug/million cells in 0.1ml in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunofluorescence (0.5-1ug/ml)
Cellular Localization
Secreted & Cell Surface
Immunogen
Mouse CD25+ CD4+ T cells
Hu-Chromosome Location
4; 4E (Mouse)
Positive Control
CD25+ CD4+ Tregs
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
References
Stephens GL, et al. 2004. J. Immunol. 173:5008. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66-70kDa (Homodimer)
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 18 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 18
NCBI Official Symbol
Tnfrsf18
NCBI Official Synonym Symbols
AITR; Gitr
NCBI Protein Information
tumor necrosis factor receptor superfamily member 18
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 18
Protein Family
UniProt Gene Name
Tnfrsf18
UniProt Synonym Gene Names
Gitr
UniProt Entry Name
TNR18_MOUSE
Uniprot Description
TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Receptor, cytokine
Cellular Component: external side of plasma membrane; integral to plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide
Research Articles on Tnfrsf18
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Product Notes
The Tnfrsf18 tnfrsf18 (Catalog #AAA438739) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GITR / Tnfrsf18 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF). Flow Cytometry (0.5-1ug/million cells in 0.1ml in 0.1ml) Immunofluorescence (0.5-1ug/ml). Researchers should empirically determine the suitability of the Tnfrsf18 tnfrsf18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GITR / Tnfrsf18, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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