Mouse anti-Human GCN5L2 Monoclonal Antibody | anti-KAT2A antibody

GCN5L2 (GCN5 General Control of Amino-acid Synthesis 5-like 2)

Cat. Num. AAA602311

• Gene Names: KAT2A; GCN5; hGCN5; GCN5L2; PCAF-b; MGC102791
• Reactivity: Human
• Applications: Western Blot, Gel Super Shift Assay
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GCN5L2; Monoclonal Antibody; GCN5L2 (GCN5 General Control of Amino-acid Synthesis 5-like 2); Anti -GCN5L2 (GCN5 General Control of Amino-acid Synthesis 5-like 2); anti-KAT2A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 8J116
• Specificity: Recognizes human GCN5L2.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 1% BSA and 0.05% sodium azide.

• Applicable Applications for anti-KAT2A antibody: Western Blot (WB), Gel Shift Assay (GS/EMSA)
• Application Notes: Suitable for use in Dot Blot and Western Blot.
• Immunogen: Partial sequence of recombinant full-length protein to human GCN5L2
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-KAT2A antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 119581207
• NCBI GeneID: 2648
• UniProt Accession #: Q92830; Q8N1A2; Q9UCW1
• Molecular Weight: 93,926 Da
• NCBI Official Full Name: GCN5 general control of amino-acid synthesis 5-like 2 (yeast), isoform CRA_c
• NCBI Official Synonym Full Names: K(lysine) acetyltransferase 2A
• NCBI Official Symbol: KAT2A
• NCBI Official Synonym Symbols: GCN5; hGCN5; GCN5L2; PCAF-b; MGC102791
• NCBI Protein Information: histone acetyltransferase KAT2A; STAF97; hsGCN5; OTTHUMP00000164769; lysine acetyltransferase 2A; histone acetyltransferase GCN5; general control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
• UniProt Protein Name: Histone acetyltransferase KAT2A
• Protein Family: Histone acetyltransferase
• UniProt Gene Name: KAT2A
• UniProt Synonym Gene Names: GCN5; GCN5L2; HGCN5
• UniProt Entry Name: KAT2A_HUMAN

NCBI Description

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]

Uniprot Description

GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.

Protein type: EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; extracellular space

Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; cell proliferation; telencephalon development; somitogenesis; establishment and/or maintenance of chromatin architecture; viral reproduction; in utero embryonic development; multicellular organism growth; neural tube closure; midbrain development; regulation of protein stability; metencephalon development; histone deubiquitination