Western Blot (WB)
(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS769621 (GCN5 antibody) at dilution of 1:800)
Rabbit anti-Human, Mouse GCN5 Polyclonal Antibody | anti-GCN5 antibody
GCN5 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS769621 (GCN5 antibody) at dilution of 1:800)
Western Blot (WB)
(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS769621 (GCN5 antibody) at dilution of 1:800)
NCBI and Uniprot Product Information
NCBI Description
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Uniprot Description
GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.
Protein type: EC 2.3.1.48; Acetyltransferase
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: extracellular space; nuclear chromatin; nucleoplasm
Molecular Function: chromatin binding; H3 histone acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; protein binding; protein phosphatase binding; transcription coactivator activity; transcription factor binding
Biological Process: cardiac muscle cell differentiation; cell proliferation; chromatin remodeling; histone deubiquitination; in utero embryonic development; intracellular distribution of mitochondria; metencephalon development; midbrain development; multicellular organism growth; neural tube closure; positive regulation of cell projection organization and biogenesis; positive regulation of gene expression, epigenetic; positive regulation of histone acetylation; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; response to nutrient levels; response to organic cyclic substance; somitogenesis; telencephalon development; transcription from RNA polymerase II promoter; viral reproduction
Research Articles on GCN5
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Product Notes
The GCN5 kat2a (Catalog #AAA769621) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCN5 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GCN5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the GCN5 kat2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCN5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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