Rabbit anti-Human IL17RE Polyclonal Antibody | anti-IL17RE antibody

IL17RE, NT (IL17RE, Interleukin-17 receptor E) (PE)

Cat. Num. AAA6310002

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IL17RE; Polyclonal Antibody; NT (IL17RE; Interleukin-17 receptor E) (PE); Interleukin-17 receptor E; anti-IL17RE antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-IL17RE antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: IL17RE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human IL17RE.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(IL17RE Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL17RE antibody detected the IL17RE protein (arrow).)

Related Product Information for anti-IL17RE antibody

This gene encodes a protein that shares limited similarity with the interleukin-17 receptor. The function of the encoded protein has not yet been determined. Alternatively spliced transcript variants have been described.

Product Categories/Family for anti-IL17RE antibody

Antibodies; Interleukin

References

Eid, N.A., et al. Malar. J. 9, 119 (2010): Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 301129210
• NCBI GeneID: 132014
• NCBI Accession #: NP_001180309.1; NP_705613.1; NP_705616.2
• NCBI GenBank Nucleotide #: NM_001193380.1
• UniProt Accession #: Q8NFR9; Q6P532; Q8N8H7; Q8N8H8; Q8TEC2; B2RB34; B2RNR1; B9EH65
• Molecular Weight: 30,781 Da
• NCBI Official Full Name: interleukin-17 receptor E isoform 6
• NCBI Official Synonym Full Names: interleukin 17 receptor E
• NCBI Official Symbol: IL17RE
• NCBI Protein Information: interleukin-17 receptor E
• UniProt Protein Name: Interleukin-17 receptor E
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RE
• UniProt Synonym Gene Names: IL-17 receptor E; IL-17RE
• UniProt Entry Name: I17RE_HUMAN

NCBI Description

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Uniprot Description

IL17RE: Receptor which can activate the MAPK signaling pathway and seems to function at or upstream of Ras. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: integral to plasma membrane; cytoplasm; extracellular region

Molecular Function: protein binding; interleukin-17 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; inflammatory response