Immunohistochemistry (IHC)
( Immunohistochemical staining of rat prostate using anti-galanin antibody Formalin fixed rat prostate slices were were stained with at 3 ug/ml.)
Galanin Recombinant Antibody | GAL recombinant antibody
Anti-Galanin [4B3]
Gene Names
GAL; ETL8; GALN; GLNN; GMAP; GAL-GMAP
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunocytochemistry
Purity
Protein A Affinity Purified
Synonyms
Galanin; Monoclonal Recombinant Antibody; Anti-Galanin [4B3]; Galanin peptide; GAL recombinant antibody
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1, Kappa
Clone Number
4B3
Specificity
The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody.
Purity/Purification
Protein A Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
123
Applicable Applications for GAL recombinant antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Blocking (BL)
Application Notes
The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
Immunogen
C-terminal fusions of KLH to human galanin
Buffer Composition
PBS only with 0.02% Proclin 300.
Chimeric Use Statement
This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Labeled Substance
None
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Immunohistochemistry (IHC)
( Immunohistochemical staining of rat prostate using anti-galanin antibody Formalin fixed rat prostate slices were were stained with at 3 ug/ml.)
Immunohistochemistry (IHC)
( Immunohistochemical staining of rat prostate using anti-galanin antibody Formalin fixed rat prostate slices were were stained with at 3 ug/ml.)
Related Product Information for GAL recombinant antibody
Recombinant monoclonal antibody to Galanin. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 4B3.
C-terminal fusions of KLH to human galanin,
C-terminal fusions of KLH to human galanin,
Product Categories/Family for GAL recombinant antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
13,302 Da
NCBI Official Full Name
galanin peptides preproprotein
NCBI Official Synonym Full Names
galanin and GMAP prepropeptide
NCBI Official Symbol
GAL
NCBI Official Synonym Symbols
ETL8; GALN; GLNN; GMAP; GAL-GMAP
NCBI Protein Information
galanin peptides
UniProt Protein Name
Galanin peptides
Protein Family
UniProt Gene Name
GAL
UniProt Synonym Gene Names
GAL1; GALN; GLNN; GMAP
NCBI Description
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
Uniprot Description
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Research Articles on GAL
Similar Products
Product Notes
The GAL gal (Catalog #AAA488327) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Galanin [4B3] reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Galanin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Blocking (BL). The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned. Researchers should empirically determine the suitability of the GAL gal for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Galanin, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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