Mouse FOXP3 Monoclonal Antibody | anti-FOXP3 antibody

FOXP3 Antibody

Cat. Num. AAA9215400

• Gene Names: FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER
• Applications: Western Blot, Immunocytochemistry
• Synonyms: FOXP3; Monoclonal Antibody; FOXP3 Antibody; Purified Mouse Monoclonal Antibody (Mab); AIID; DIETER; Forkhead box P3; Forkhead box protein P3; foxp3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; SCURFIN; XPID.; anti-FOXP3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Form/Format: Ascites containing with 0.02% sodium azide and 50% glycerol.
• Sequence Length: 396

• Applicable Applications for anti-FOXP3 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: WB ~~ 1:300; ICC ~~ 1:100
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of FOXP3 in CHO-K1 cell lysate(A)and CHO-K1 transfected by FOXP3(B)cell lysate using FOXP3 mouse mAb (1:300 diluted).Predicted band size:47KDa.Observed band size:50KDa.)

Immunocytochemistry (ICC)

(Immunocytochemistry staining of CHO-K1 cells which transfected by FOXP3 fixed in 1% Paraformaldehyde and using anti-FOXP3 mouse mAb (dilution 1:100).)

Related Product Information for anti-FOXP3 antibody

Probable transcription factor. Plays a critical role in the control of immune response.

Product Categories/Family for anti-FOXP3 antibody

Cell Biology; Immunology

References

Brunkow M.E.,et al.Nat. Genet. 27:68-73(2001). Wang J.,et al.Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. Kaur G.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. Lin L.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Ross M.T.,et al.Nature 434:325-337(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 167466190
• NCBI GeneID: 50943
• NCBI Accession #: NP_001107849.1
• NCBI GenBank Nucleotide #: NM_001114377.1
• UniProt Accession #: Q9BZS1; O60827; Q14DD8; Q4ZH51; A5HJT1; B7ZLG0; B9UN80
• Molecular Weight: 47244
• NCBI Official Full Name: forkhead box protein P3 isoform b
• NCBI Official Synonym Full Names: forkhead box P3
• NCBI Official Symbol: FOXP3
• NCBI Official Synonym Symbols: JM2; AIID; IPEX; PIDX; XPID; DIETER
• NCBI Protein Information: forkhead box protein P3
• UniProt Protein Name: Forkhead box protein P3
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXP3
• UniProt Synonym Gene Names: IPEX
• UniProt Entry Name: FOXP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Cell cycle regulation; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: protein complex; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; NF-kappaB binding; protein binding; NFAT protein binding; protein homodimerization activity; sequence-specific DNA binding; histone deacetylase binding; metal ion binding; transcription factor activity; transcription corepressor activity

Biological Process: negative regulation of interleukin-10 production; positive regulation of transcription, DNA-dependent; myeloid cell homeostasis; negative regulation of cytokine secretion; T cell receptor signaling pathway; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; T cell homeostasis; tolerance induction to self antigen; anatomical structure morphogenesis; transcription, DNA-dependent; response to virus; negative regulation of transcription factor activity; negative regulation of immune response; cytokine production; negative regulation of T cell cytokine production; positive regulation of peripheral T cell tolerance induction; inhibition of NF-kappaB transcription factor; regulation of T cell anergy; negative regulation of interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; negative regulation of cytokine biosynthetic process; negative regulation of interleukin-4 production; T cell activation; negative regulation of activated T cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of histone acetylation; negative regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-4 production; negative regulation of cell proliferation; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell proliferation; regulation of transcription, DNA-dependent; B cell homeostasis; negative regulation of interferon-gamma production; cell differentiation; positive regulation of T cell anergy; regulation of isotype switching to IgG isotypes; positive regulation of transforming growth factor-beta1 production; negative regulation of chronic inflammatory response; negative regulation of histone deacetylation; T cell mediated immunity; positive regulation of immature T cell proliferation in the thymus; negative regulation of tumor necrosis factor production; chromatin remodeling; negative regulation of interleukin-17 production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; negative regulation of interleukin-2 biosynthetic process; positive regulation of histone acetylation

Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked