ELISA (EIA)
(Sandwich ELISA analysis of human fibrinogen using Mouse anti Human fibrinogen as a capture reagent and biotinylated Mouse anti Human fibrinogen (MBS226147) as a detection reagent with purified human fibrinogen as the antigen. Detection was perf)
Mouse anti-Human Fibrinogen Monoclonal Antibody | anti-FGG antibody
Mouse anti Human Fibrinogen:Biotin
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Purified IgG conjugated to Biotin - liquid
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
ELISA (EIA)
(Sandwich ELISA analysis of human fibrinogen using Mouse anti Human fibrinogen as a capture reagent and biotinylated Mouse anti Human fibrinogen (MBS226147) as a detection reagent with purified human fibrinogen as the antigen. Detection was perf)
ELISA (EIA)
(Sandwich ELISA analysis of human fibrinogen using Mouse anti Human fibrinogen as a capture reagent and biotinylated Mouse anti Human fibrinogen (MBS226147) as a detection reagent with purified human fibrinogen as the antigen. Detection was perf)
In response to bleeding, the coagulation cascade is activated which results in the conversion of fibrinogen to fibrin. The resulting fibrin spontaneously forms polymers creating an insoluble gel which combines with platelets to form a spongy mass. This mass is the blood clot which subsequently hardens to prevent further bleeding from the blood vessel (Tiscia & Margaglione 2018). The impairment of this conversion from fibrinogen to fibrin is associated with a range of pathologies including coagulopathies, ischemic stroke and obstetrical complications. It is also implicated in various neurological diseases such as Alzheimer’s, multiple sclerosis and traumatic central nervous system injury (Petersen et al. 2018).
The biotinylated Mouse anti Human fibrinogen antibody, clone AB10-3C12 can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human fibrinogen antibody, clone AB05-1F11 as the capture antibody.
NCBI and Uniprot Product Information
Uniprot Description
FGG: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: cell surface; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; plasma membrane
Molecular Function: cell adhesion molecule binding; protein binding; receptor binding; structural molecule activity
Biological Process: blood coagulation; cell-matrix adhesion; cellular protein complex assembly; extracellular matrix organization and biogenesis; fibrinolysis; plasminogen activation; platelet degranulation; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein secretion; positive regulation of vasoconstriction; protein polymerization; protein secretion; response to calcium ion
Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
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Product Notes
The FGG fgg (Catalog #AAA226147) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human Fibrinogen:Biotin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fibrinogen can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1.0ug/ml. Researchers should empirically determine the suitability of the FGG fgg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibrinogen, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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