Mouse anti-Human FceRI, alpha Monoclonal Antibody | anti-FCER1A antibody

FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, High Affinity Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) (PE)

Cat. Num. AAA631461

• Gene Names: FCER1A; FCE1A; FcERI
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: FceRI; alpha; Monoclonal Antibody; alpha (Fc epsilon RI alpha; FCE1A; FCER1A; High Affinity Immunoglobulin epsilon Receptor Subunit alpha; IgE Receptor) (PE); Anti -FceRI; anti-FCER1A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 10C204
• Specificity: Recognizes human FceRI, alpha. Specifically recognizes the extracellular D1 domain of FceRI, alpha. Primarily expressed on mast cells and basophils but expression has also been reported on monocytes, Langerhans cells and dendritic cells from patients with atopic diseases.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, 1% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE). Reconstitute with 1ml sterile ddH2O.

• Applicable Applications for anti-FCER1A antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry.; Dilution: Flow Cytometry: Neat; 10ul labels 10e6 cells in 100ul
• Immunogen: Human Fc Epsilon R1 alpha
• Hybridoma: Sp2/0-Ag14 myeloma cells with spleen cells from Balb/c mice.
• Preparation and Storage: May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Stable for at least 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

Related Product Information for anti-FCER1A antibody

The human high affinity Fc receptor for IgE (Fc epsilon R1), plays a central role in the IgE-mediated allergic response. Fc epsilon R1 consists of four subunits, a high affinity IgE binding alpha subunit, a beta chain and two di-sulphide linked gamma subunits.

Product Categories/Family for anti-FCER1A antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 15929530
• NCBI GeneID: 2205
• UniProt Accession #: P12319
• Molecular Weight: 29,596 Da
• NCBI Official Full Name: Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
• NCBI Official Synonym Full Names: Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
• NCBI Official Symbol: FCER1A
• NCBI Official Synonym Symbols: FCE1A; FcERI
• NCBI Protein Information: high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
• UniProt Protein Name: High affinity immunoglobulin epsilon receptor subunit alpha
• Protein Family: High affinity immunoglobulin epsilon receptor
• UniProt Gene Name: FCER1A
• UniProt Synonym Gene Names: FCE1A; FcERI
• UniProt Entry Name: FCERA_HUMAN

NCBI Description

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Uniprot Description

Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Subunit structure: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Sequence similarities: Contains 2 Ig-like (immunoglobulin-like) domains.