Mouse Fatty Acid Binding Protein, Heart Monoclonal Antibody | anti-FABP7 antibody

Fatty Acid Binding Protein, Heart (BSA, Azide Free) (FABP)

Cat. Num. AAA609245

• Gene Names: FABP7; MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• Reactivity: Human, Mouse, Porcine, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Fatty Acid Binding Protein; Heart; Monoclonal Antibody; Heart (BSA; Azide Free) (FABP); Anti -Fatty Acid Binding Protein; anti-FABP7 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Porcine, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 6A546
• Specificity: Recognizes human heart FABP of both natural and recombinant origin. Does not bind to human intestinal or liver FABP. Can be used to detect ischemia areas of human heart. Species Crossreactivity: rat, mouse and porcine
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS. Available with BSA and sodium azide. See F0019-75H.

• Applicable Applications for anti-FABP7 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Immunoprecipitation, Western Blot and Purification.; Dilution: Western Blot: 1:50 using reduced conditions. Detected a band of ~15kD.
• Immunogen: Purified human Fatty Acid Binding Protein, Heart (FABP).
• Positive Control: Heart cells, recombinant human FABP
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-FABP7 antibody

The human Fatty Acid Binding Protein is derived from the human FABP3 gene. FABPs are small intracellular proteins (~13-14kD) with a high degree of tissue specificity that bind long chain fatty acids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. H-FABP is localized in the heart, skeletal and smooth muscle, mammary epithelial cells, aorta, distal tubules of the kidney, lung, brain, placenta, and ovary. It is also useful as marker for brain damage.

Product Categories/Family for anti-FABP7 antibody

Antibodies; Abs to Fatty Acid Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 2645203
• NCBI GeneID: 2173
• UniProt Accession #: O15540; O14951; Q6IAU7; B2R4L1; Q9H047
• Molecular Weight: 14,889 Da
• NCBI Official Full Name: fatty acid binding protein
• NCBI Official Synonym Full Names: fatty acid binding protein 7, brain
• NCBI Official Symbol: FABP7
• NCBI Official Synonym Symbols: MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• NCBI Protein Information: fatty acid-binding protein, brain; OTTHUMP00000017118; OTTHUMP00000017119; brain lipid binding protein; brain lipid-binding protein; fatty acid-binding protein 7; brain-type fatty acid-binding protein; mammary-derived growth inhibitor related; mammary-derived growth inhibitor-related
• UniProt Protein Name: Fatty acid-binding protein, brain
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP7
• UniProt Synonym Gene Names: BLBP; FABPB; MRG
• UniProt Entry Name: FABP7_HUMAN

NCBI Description

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq]

Uniprot Description

FABP7: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding; Cell cycle regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: cell projection; cell soma; cytoplasm; nucleus

Molecular Function: transporter activity; lipid binding

Biological Process: nervous system development; negative regulation of cell proliferation; epithelial cell proliferation; prepulse inhibition; neurogenesis; transport; cell proliferation in forebrain