Structure
(Schematic structure of mouse FasL (peptide, aa 196-220))
Rat anti-Mouse FasL Monoclonal Antibody | anti-CD178; CD95L; APO-1L; TNFSF 6 antibody
FasL (mouse) monoclonal antibody (H11) (biotin conjugate)
Stable for at least 6 months after receipt when stored at +4 degree C undiluted. Avoid freeze/thaw cycles.
Structure
(Schematic structure of mouse FasL (peptide, aa 196-220))
Structure
(Schematic structure of mouse FasL (peptide, aa 196-220))
NCBI and Uniprot Product Information
Uniprot Description
FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Apoptosis; Cytokine
Cellular Component: caveola; cell surface; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; external side of plasma membrane; extracellular region; extracellular space; integral to membrane; lipid raft; lysosome; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; death receptor binding; tumor necrosis factor receptor binding
Biological Process: apoptosis; caspase activation; cellular chloride ion homeostasis; endosomal lumen acidification; immune response; induction of apoptosis via death domain receptors; inflammatory cell apoptosis; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptosis; regulation of transcription, DNA-dependent; retinal cell programmed cell death; transcription, DNA-dependent
Research Articles on CD178; CD95L; APO-1L; TNFSF 6
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Product Notes
The CD178; CD95L; APO-1L; TNFSF 6 faslg (Catalog #AAA565022) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The FasL (mouse) monoclonal antibody (H11) (biotin conjugate) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FasL can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Western Blot (WB). For immunohistochemistry, we recommend MAb to FasL (A11). For the detection of human FasL by flow cytometry or Western blot, we recommmend MAb to FasL (human) (Mike-2). Researchers should empirically determine the suitability of the CD178; CD95L; APO-1L; TNFSF 6 faslg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FasL, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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