Mouse anti-Human EXOSC2 Monoclonal Antibody | anti-EXOSC2 antibody

EXOSC2 Mouse Monoclonal

Cat. Num. AAA769134

• Gene Names: EXOSC2; p7; RRP4; Rrp4p; hRrp4p
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: EXOSC2; Monoclonal Antibody; EXOSC2 Mouse Monoclonal; anti-EXOSC2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 88

• Applicable Applications for anti-EXOSC2 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: Exosome component 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skin cancer slide using MBS769134 (EXOSC2 Antibody) at dilution of 1:50)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS769134 (EXOSC2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 124504299
• NCBI GeneID: 23404
• Molecular Weight: 29,408 Da
• NCBI Official Full Name: EXOSC2 protein, partial
• NCBI Official Synonym Full Names: exosome component 2
• NCBI Official Symbol: EXOSC2
• NCBI Official Synonym Symbols: p7; RRP4; Rrp4p; hRrp4p
• NCBI Protein Information: exosome complex component RRP4
• UniProt Protein Name: Exosome complex component RRP4
• UniProt Gene Name: EXOSC2
• UniProt Synonym Gene Names: RRP4
• UniProt Entry Name: EXOS2_HUMAN

Uniprot Description

RRP4: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Protein type: RNA processing; Ribonuclease; Nucleolus; EC 3.1.13.-

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; 7S RNA binding; exoribonuclease activity; protein binding

Biological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of cell growth; regulation of mRNA stability; rRNA processing