Western Blot (WB)
(Figure 1: Western blot analysis using EphA6 mouse mAb against truncated MBP-EphA6 recombinant protein (1) and truncated GST-EphA6(aa695-795) recombinant protein (2).)
Mouse anti-Human EphA6 Monoclonal Antibody | anti-EphA6 antibody
EphA6 Antibody
Gene Names
EPHA6; EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Affinity-Chromatography
Synonyms
EphA6; Monoclonal Antibody; EphA6 Antibody; Ehk 2; EHK-2; Ehk2; EPH homology kinase 2; Eph Receptor A6; Epha6; EPHA6_HUMAN; ephrin receptor EphA6; ephrin type A receptor 6; Ephrin type-A receptor 6; Hek12; anti-EphA6 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Specificity
EphA6 antibody detects endogenous levels of total EphA6
Purity/Purification
Affinity-Chromatography
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
398
Applicable Applications for anti-EphA6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
ELISA: 1:10000
WB: 1:500-1:2000
WB: 1:500-1:2000
Immunogen
Purified recombinant fragment of human EphA6 expressed in E. Coli
Subcellular Location
Membrane.
Tissue Specificity
Expressed in brain and testis.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Figure 1: Western blot analysis using EphA6 mouse mAb against truncated MBP-EphA6 recombinant protein (1) and truncated GST-EphA6(aa695-795) recombinant protein (2).)
Western Blot (WB)
(Figure 1: Western blot analysis using EphA6 mouse mAb against truncated MBP-EphA6 recombinant protein (1) and truncated GST-EphA6(aa695-795) recombinant protein (2).)
Related Product Information for anti-EphA6 antibody
Description: EphA6: EPH receptor A6. The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1(Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3(Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. Ephrin-A2(ELF-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Subunit Structure: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Subunit Structure: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 116 kDa
Predicted: 117 kDa
Predicted: 117 kDa
NCBI Official Full Name
ephrin type-A receptor 6 isoform c
NCBI Official Synonym Full Names
EPH receptor A6
NCBI Official Symbol
EPHA6
NCBI Official Synonym Symbols
EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066
NCBI Protein Information
ephrin type-A receptor 6
UniProt Protein Name
Ephrin type-A receptor 6
Protein Family
UniProt Gene Name
EPHA6
UniProt Synonym Gene Names
EHK2; HEK12; EHK-2; EK12
Uniprot Description
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling ().
Research Articles on EphA6
1. The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population.
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Product Notes
The EphA6 epha6 (Catalog #AAA9602807) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The EphA6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EphA6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). ELISA: 1:10000 WB: 1:500-1:2000. Researchers should empirically determine the suitability of the EphA6 epha6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EphA6, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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