Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-3: A549 cells, mouse heart tissue, Hela cells, Primary antibody: 822614(LEPREL2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds)
Rabbit anti-Human, Mouse LEPREL2 Polyclonal Antibody | anti-LEPREL2 antibody
LEPREL2 Rabbit pAb
IHC: 1:50-1:200
Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-3: A549 cells, mouse heart tissue, Hela cells, Primary antibody: 822614(LEPREL2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds)
Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-3: A549 cells, mouse heart tissue, Hela cells, Primary antibody: 822614(LEPREL2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human rectal cancer tissue using 822614(LEPREL2 Antibody) at dilution 1/50. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human rectal cancer tissue using 822614(LEPREL2 Antibody) at dilution 1/50. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human placenta tissue using 822614(LEPREL2 Antibody) at dilution 1/50. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human placenta tissue using 822614(LEPREL2 Antibody) at dilution 1/50. (Original magnification: ×200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
Uniprot Description
LEPREL2: Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. Belongs to the leprecan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.7; Oxidoreductase
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: endoplasmic reticulum lumen
Molecular Function: procollagen-proline 3-dioxygenase activity; L-ascorbic acid binding; iron ion binding
Biological Process: negative regulation of cell proliferation; extracellular matrix organization and biogenesis; peptidyl-proline hydroxylation
Research Articles on LEPREL2
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Product Notes
The LEPREL2 leprel2 (Catalog #AAA4757994) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LEPREL2 Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LEPREL2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the LEPREL2 leprel2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LEPREL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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