Mouse DUSP5 Monoclonal Antibody | anti-DUSP5 antibody

DUSP5 (Dual Specificity Phosphatase 5, HVH3)

Cat. Num. AAA600381

• Gene Names: DUSP5; DUSP; HVH3
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: DUSP5; Monoclonal Antibody; DUSP5 (Dual Specificity Phosphatase 5; HVH3); Anti -DUSP5 (Dual Specificity Phosphatase 5; anti-DUSP5 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 8C122
• Specificity: Recognizes human DUSP5.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-DUSP5 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human DUSP5
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-DUSP5 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 62865890
• NCBI GeneID: 1847
• NCBI Accession #: NP_004410.3
• NCBI GenBank Nucleotide #: NM_004419.3
• UniProt Accession #: Q16690; Q12997; Q5T603; Q59EI8
• Molecular Weight: 42,047 Da
• NCBI Official Full Name: dual specificity protein phosphatase 5
• NCBI Official Synonym Full Names: dual specificity phosphatase 5
• NCBI Official Symbol: DUSP5
• NCBI Official Synonym Symbols: DUSP; HVH3
• NCBI Protein Information: dual specificity protein phosphatase 5; OTTHUMP00000020476; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase
• UniProt Protein Name: Dual specificity protein phosphatase 5
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP5
• UniProt Synonym Gene Names: VH3
• UniProt Entry Name: DUS5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]

Uniprot Description

DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleus

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: endoderm formation; protein amino acid dephosphorylation; inactivation of MAPK activity