Human Dual specificity protein phosphatase 5 ELISA Kit | DUSP5 elisa kit

Human Dual specificity protein phosphatase 5 ELISA Kit

Cat. Num. AAA2883015

• Gene Names: DUSP5; DUSP; HVH3
• Reactivity: Human
• Synonyms: Dual specificity protein phosphatase 5; Human Dual specificity protein phosphatase 5 ELISA Kit; Dual specificity protein phosphatase hVH3; DUSP5; VH3; 3.1.3.16; DUSP5 elisa kit

• Reactivity: Human
• Sequence Length: 384

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.11ng/mL
• Intra-Assay CV: <=7.2%
• Inter-Assay CV: <=10.5%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 62865890
• NCBI GeneID: 1847
• NCBI Accession #: NP_004410.3
• NCBI GenBank Nucleotide #: NM_004419.3
• UniProt Accession #: Q16690; Q12997; Q5T603
• Molecular Weight: 42,047 Da
• NCBI Official Full Name: dual specificity protein phosphatase 5
• NCBI Official Synonym Full Names: dual specificity phosphatase 5
• NCBI Official Symbol: DUSP5
• NCBI Official Synonym Symbols: DUSP; HVH3
• NCBI Protein Information: dual specificity protein phosphatase 5
• UniProt Protein Name: Dual specificity protein phosphatase 5
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP5
• UniProt Synonym Gene Names: VH3
• UniProt Entry Name: DUS5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Description

DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activity

Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; endoderm formation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; protein amino acid dephosphorylation; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway