DNA Polymerase, epsilon Monoclonal Antibody
Anti - DNA Polymerase, epsilon (e)
Reactivity
Bovine, Human, Monkey, Mouse
Purity
Purified by Protein A/G column chromatography
Synonyms
DNA Polymerase; epsilon; Monoclonal Antibody; Anti - DNA Polymerase; epsilon (e); anti-DNA Polymerase; epsilon antibody
Host
Host: Mouse
Source: Human
Source: Human
Reactivity
Bovine, Human, Monkey, Mouse
Clonality
Monoclonal
Isotype
IgG2k
Clone Number
3H15
Specificity
Crossreact with mouse, monkey and cow. It is specific for DNA Pol e and Pol e*. No crossreactivity is seen with DNA Pol a or d. Antibody crossreactivity in various other species has not been studied
Purity/Purification
Purified by Protein A/G column chromatography
Form/Format
Affinity Purified
Supplied as a liquid in 10 mM PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, 40% glycerol.
Supplied as a liquid in 10 mM PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, 40% glycerol.
Concentration
0.2mg/ml (varies by lot)
Immunogen
Purified Human recombinant DNA Pol epsilon aa1-176
Preparation and Storage
-20 degree C
Related Product Information for anti-DNA Polymerase, epsilon antibody
Reactive oxygen species (H2O2·, OH·, O2, HOCL) generated during normal cellular activities or by ionizing radiation and by many oxidizing/alkylating agents can induce a wide variety of lesions in DNA ranging from oxidized bases (8-oxoguanine and thymine glycol), base loss and DNA strand breaks with modified ends such as 3\'-phosphate and 3\'-phopshoglycolate. Unrepaired damaged/modified DNA has been implicated in aging and cancer. DNA Pol epsilon is expressed in proliferating cells. It is implicated in repair of UV-damaged DNA. DNA Pol epsilon is a protein of >200kD protein complex. The 140-KDa fragment, DNA Pol e* is a truncated form of DNA Pol e that is missing the C-terminal fragment.
Product Categories/Family for anti-DNA Polymerase, epsilon antibody
References
• 1. Uitto L et al (1995) Nucl. Acid Res. 23, 244-247; Tuusa j et al (1995) Nucl. Acid Res. 23, 2178-2183Zlotkin T et al (19960 EMBO J. 15, 2298-2305; Wood Rd et al (1997) carcinogenesis 18, 605-610; Prapurna DR et al (1997) J Develop. Neurosci. 15, 67-73; Chui G et al (1995) J. Biol. Chem. 270, 691-698; Chui GS and Linn S (1995) Methods Enzymol. 262; 93-98.
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Product Notes
The DNA Polymerase, epsilon (Catalog #AAA603741) is an Antibody produced from Host: Mouse Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - DNA Polymerase, epsilon (e) reacts with Bovine, Human, Monkey, Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "DNA Polymerase, epsilon, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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