Mouse DLGAP1 Monoclonal Antibody | anti-SHANK1 antibody

DLGAP1 (pan-SAPAP, DAP-1, Disks large-associated protein 1, Gkap, Guanylate kinase-associated protein, PSD-95/SAP90-binding protein 1, rGKAP, SAP90/PSD-95-associated protein 1, SAPAP1)

Cat. Num. AAA606878

• Gene Names: SHANK1; SSTRIP; SPANK-1; synamon
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: DLGAP1; Monoclonal Antibody; DLGAP1 (pan-SAPAP; DAP-1; Disks large-associated protein 1; Gkap; Guanylate kinase-associated protein; PSD-95/SAP90-binding protein 1; rGKAP; SAP90/PSD-95-associated protein 1; SAPAP1); Anti -DLGAP1 (pan-SAPAP; anti-SHANK1 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2B
• Clone Number: 10F766
• Specificity: Recognizes rat SAPAP1. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.

• Applicable Applications for anti-SHANK1 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot and Immunocytochemistry.; Dilution: Western Blot:1-10ug/ml; Immunocytochemistry:0.1-1ug/ml
• Immunogen: Fusion protein aa 772-992 (C-terminus) of rat SAPAP1 (also known as disks large-associated protein 1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95 associated/binding protein 1, accession number P97836).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis rat brain membrane lysates using MBS606878 at 1:1000 dilution.)

Related Product Information for anti-SHANK1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or

Product Categories/Family for anti-SHANK1 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 120587025
• NCBI GeneID: 50944
• NCBI Accession #: NP_057232.2
• NCBI GenBank Nucleotide #: NM_016148.2
• UniProt Accession #: Q9Y566; Q9NYW9; A8MXP5; B7WNY6
• Molecular Weight: 224,959 Da
• NCBI Official Full Name: SH3 and multiple ankyrin repeat domains protein 1
• NCBI Official Synonym Full Names: SH3 and multiple ankyrin repeat domains 1
• NCBI Official Symbol: SHANK1
• NCBI Official Synonym Symbols: SSTRIP; SPANK-1; synamon
• NCBI Protein Information: SH3 and multiple ankyrin repeat domains protein 1; OTTHUMP00000174437; OTTHUMP00000174438; SSTR-interacting protein; somatostatin receptor-interacting protein
• UniProt Protein Name: SH3 and multiple ankyrin repeat domains protein 1
• Protein Family: SH3 and multiple ankyrin repeat domains protein
• UniProt Gene Name: SHANK1
• UniProt Entry Name: SHAN1_HUMAN

Uniprot Description

SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: postsynaptic membrane; neuron projection; membrane; dendrite; cytoplasm; dendritic spine; plasma membrane; ionotropic glutamate receptor complex; excitatory synapse; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: somatostatin receptor binding; protein C-terminus binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain binding

Biological Process: synapse maturation; negative regulation of actin filament bundle formation; olfactory behavior; righting reflex; cytoskeletal anchoring; social behavior; habituation; determination of affect; long-term memory; adult behavior; protein complex assembly; neuromuscular process controlling balance; associative learning