Rabbit anti-Mouse DKK3 Monoclonal Antibody | anti-DKK3 antibody
Recombinant Anti-DKK3 Antibody, Rabbit Monoclonal
Gene Names
Dkk3; dkk-3; C87148; mDkk-3; AW061014
Reactivity
Mouse
Applications
ELISA, ELISA
Purity
Protein A
Synonyms
DKK3; Monoclonal Antibody; Recombinant Anti-DKK3 Antibody; Rabbit Monoclonal; DKK3 Antibody; Rabbit MAb; dickkopf WNT signaling pathway inhibitor 3; Anti-AW061014 Antibody; Anti-C87148 Antibody; anti-DKK3 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
019
Specificity
Mouse Dkk3.
No cross-reactivity in ELISA with Human DKK3
No cross-reactivity in ELISA with Human DKK3
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-DKK3 antibody
ELISA (EIA), ELISA (EIA) (Cap)
Application Notes
ELISA: 1:5000-1:10,000
ELISA (Cap): 1:250-1:2000
ELISA (Cap): This antibody will detect Mouse DKK3 in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody.
ELISA (Cap): 1:250-1:2000
ELISA (Cap): This antibody will detect Mouse DKK3 in ELISA pair set.
In a sandwich ELISA, it can be used as capture antibody.
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Mouse Dkk3 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DKK3 (rM DKK3).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-DKK3 antibody
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.
Product Categories/Family for anti-DKK3 antibody
References
Yue W, et al., 2008. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis, 29 (1): 84-92.Ding Z, et al., 2009. Promoter methylation and mRNA expression of DKK3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol, 15 (21):2595-601.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38,388 Da
NCBI Official Full Name
dickkopf-related protein 3 isoform b
NCBI Official Synonym Full Names
dickkopf WNT signaling pathway inhibitor 3
NCBI Official Symbol
Dkk3
NCBI Official Synonym Symbols
dkk-3; C87148; mDkk-3; AW061014
NCBI Protein Information
dickkopf-related protein 3
UniProt Protein Name
Dickkopf-related protein 3
Protein Family
UniProt Gene Name
Dkk3
UniProt Synonym Gene Names
Dickkopf-3; Dkk-3; mDkk-3
Uniprot Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease ().
