Mouse anti-Human Delta-like 1 Monoclonal Antibody | anti-DLL3 antibody

Delta-like 1 (DLL1, Delta1, DL1, H-Delta-1, UNQ146/PRO172)

Cat. Num. AAA607077

• Gene Names: DLL3; SCDO1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Delta-like 1; Monoclonal Antibody; Delta-like 1 (DLL1; Delta1; DL1; H-Delta-1; UNQ146/PRO172); Anti -Delta-like 1 (DLL1; anti-DLL3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G346
• Specificity: Recognizes human Delta-like 1.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS, pH7.4. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-DLL3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Partial recombinant protein of human Delta-1 (aa18-109) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(WB detection of GST tagged recombinant Delta-1 using MBS607077. The GST tag has a molecular weight of 26kD.)

Related Product Information for anti-DLL3 antibody

Delta-1 acts as a ligand for Notch receptors. It blocks the differentiation of progenitor cells into the B-cell lineage while promoting cells with the characteristics of a T-cel/NK-cell precursor. It is expressed in heart and pancreas, with lower expression in brain and muscle and very little expression in placenta, lung, liver and kidney. Delta-1 is a transmembrane protein which is ubiquinated by MIB, leading to its endocytosis and subsequent degradation. It contains one DSL domain and eight EGF-like domains.

Product Categories/Family for anti-DLL3 antibody

Antibodies; Abs to Notch Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 8393264
• NCBI GeneID: 10683
• NCBI Accession #: NP_058637.1
• NCBI GenBank Nucleotide #: NM_016941.3
• UniProt Accession #: Q9NYJ7; Q8NBS4; E9PFG2
• Molecular Weight: 64,618 Da
• NCBI Official Full Name: delta-like protein 3 isoform 1
• NCBI Official Synonym Full Names: delta-like 3 (Drosophila)
• NCBI Official Symbol: DLL3
• NCBI Official Synonym Symbols: SCDO1
• NCBI Protein Information: delta-like protein 3; delta3; drosophila Delta homolog 3
• UniProt Protein Name: Delta-like protein 3
• Protein Family: Delta-like protein
• UniProt Gene Name: DLL3
• UniProt Synonym Gene Names: Delta3
• UniProt Entry Name: DLL3_HUMAN

NCBI Description

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: integral to membrane

Molecular Function: Notch binding

Biological Process: paraxial mesoderm development; compartment specification; somitogenesis; Notch signaling pathway; skeletal development; negative regulation of neurogenesis

Disease: Spondylocostal Dysostosis 1, Autosomal Recessive