Mouse Cyclophilin-B Monoclonal Antibody | anti-PPIB antibody

Mouse Anti Human Cyclophilin-B

Cat. Num. AAA140239

• Gene Names: PPIB; OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• Applications: ELISA, Western Blot
• Purity: Cyclophilin-B antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Cyclophilin-B; Monoclonal Antibody; Mouse Anti Human Cyclophilin-B; Cyclophilin B Antibody; Mouse Anti Human; Peptidylprolyl isomerase B; PPIase; Rotamase; S-cyclophilin; PPIB; cyclophilin-like protein; peptidyl-prolyl cis-trans isomerase B; Cyclophilin B; SCYLP; CYPB; CYP-S1; MGC2224; MGC14109; anti-PPIB antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 heavy chain and kappa light chain
• Clone Number: Pk2E2AT
• Purity/Purification: Cyclophilin-B antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 208

• Applicable Applications for anti-PPIB antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Cyclophilin-B antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.
• Immunogen: Anti-human Cyclophilin-B mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Cyclophilin-B amino acids 26-216 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-PPIB antibody

Introduction: Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.

Product Categories/Family for anti-PPIB antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 181335
• NCBI GeneID: 5479
• Molecular Weight: 23,743 Da
• NCBI Official Full Name: cyclophilin B
• NCBI Official Synonym Full Names: peptidylprolyl isomerase B (cyclophilin B)
• NCBI Official Symbol: PPIB
• NCBI Official Synonym Symbols: OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase B; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; rotamase B
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase B
• Protein Family: Probable peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: PPIB
• UniProt Synonym Gene Names: CYPB; PPIase B; SCYLP
• UniProt Entry Name: PPIB_HUMAN

NCBI Description

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

Uniprot Description

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: Secreted, signal peptide; Cyclophilin; Secreted; EC 5.2.1.8; Chaperone; RNA-binding; Isomerase

Chromosomal Location of Human Ortholog: 15q21-q22

Cellular Component: focal adhesion; smooth endoplasmic reticulum; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; nucleus

Molecular Function: collagen binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; protein complex binding; peptide binding

Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein stabilization; positive regulation of multicellular organism growth

Disease: Osteogenesis Imperfecta, Type Ix