anti-Human cTnT, Clone 1D7 Monoclonal Antibody | anti-TNNT2 antibody

Anti Human cTnT, Clone 1D7

Cat. Num. AAA135086

• Gene Names: TNNT2; CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: IgG fraction
• Synonyms: cTnT; Clone 1D7; Monoclonal Antibody; Anti Human cTnT; anti-TNNT2 antibody

• Host: Host: Mouse; Source: Hybridoma cell culture
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG3
• Clone Number: 1D7-C11-D7
• Purity/Purification: IgG fraction
• Form/Format: Frozen liquid
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 295

• Applicable Applications for anti-TNNT2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Full length native protein (purified) (Human).
• Target Information: Recognises cTnT
• Target Molecular Weight: 36000
• Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
• Extinction Coefficient: 1.36
• Preparation and Storage: Store at -70 degree C. Shelf Life: 5 years from delivery

Related Product Information for anti-TNNT2 antibody

Mouse monoclonal antibody to human Cardiac Troponin T (cTnT). IgG fraction purified by immobilized Protein A. Clone 1D7-C11-D7, isotype IgG13.

Product Categories/Family for anti-TNNT2 antibody

Cardiac Troponin T (cTnT); Monoclonal Antibodies to Human Cardiac Troponin T

NCBI and Uniprot Product Information

• NCBI GI #: 48255877
• NCBI GeneID: 7139
• NCBI Accession #: NP_000355.2
• NCBI GenBank Nucleotide #: NM_000364.3
• UniProt Accession #: P45379; O60214; Q99596; Q99597; Q9BUF6; Q9UM96; A2TDB9; A8K3K6
• Molecular Weight: 160,000
• NCBI Official Full Name: troponin T, cardiac muscle isoform 1
• NCBI Official Synonym Full Names: troponin T type 2 (cardiac)
• NCBI Official Symbol: TNNT2
• NCBI Official Synonym Symbols: CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6
• NCBI Protein Information: troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
• UniProt Protein Name: Troponin T, cardiac muscle
• Protein Family: Troponin
• UniProt Gene Name: TNNT2
• UniProt Synonym Gene Names: TnTc; cTnT
• UniProt Entry Name: TNNT2_HUMAN

NCBI Description

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: positive regulation of ATPase activity; atrial cardiac muscle morphogenesis; regulation of muscle contraction; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2