Rabbit anti-Human CSF2RB  Monoclonal Antibody | anti-CSF2RB  antibody

Rabbit anti Human CSF2RB  Monoclonal Antibody

Cat. Num. AAA2544019

• Gene Names: CSF2RB; CD131; IL3RB; IL5RB; SMDP5; CDw131
• Reactivity: Human
• Applications: ELISA
• Synonyms: CSF2RB ; Monoclonal Antibody; Rabbit anti Human CSF2RB Monoclonal Antibody; anti-CSF2RB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 897

• Applicable Applications for anti-CSF2RB antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CSF2Rb. The detection limit for Human CSF2Rb is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human CD131/CSF2RB/IL3RB/IL5RB protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CSF2RB  antibody

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

NCBI and Uniprot Product Information

• NCBI GI #: 4559408
• NCBI GeneID: 1439
• NCBI GenBank Nucleotide #: NM_000395.2
• Molecular Weight: 97,976 Da
• NCBI Official Full Name: cytokine receptor common subunit beta
• NCBI Official Synonym Full Names: colony stimulating factor 2 receptor beta common subunit
• NCBI Official Symbol: CSF2RB
• NCBI Official Synonym Symbols: CD131; IL3RB; IL5RB; SMDP5; CDw131
• NCBI Protein Information: cytokine receptor common subunit beta
• UniProt Protein Name: Cytokine receptor common subunit beta
• UniProt Gene Name: CSF2RB
• UniProt Synonym Gene Names: IL3RB; IL5RB
• UniProt Entry Name: IL3RB_HUMAN

NCBI Description

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Uniprot Description

CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; plasma membrane

Molecular Function: interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: cellular protein metabolic process; MAPKKK cascade; respiratory gaseous exchange

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5