Immunohistochemistry (IHC)
(Immunochemical staining of human CRIP2 in human placenta with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).)
Mouse anti-Human CRIP2 Monoclonal Antibody | anti-CRIP2 antibody
Anti-CRIP2 Antibody, Mouse Monoclonal
Gene Names
CRIP2; CRIP; CRP2; ESP1
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A
Synonyms
CRIP2; Monoclonal Antibody; Anti-CRIP2 Antibody; Mouse Monoclonal; CRIP2 Antibody; Mouse MAb; cysteine-rich protein 2; Anti-CRIP Antibody; Anti-CRP2 Antibody; Anti-ESP1 Antibody; anti-CRIP2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
05
Specificity
Human CRIP2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CRIP2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
Recombinant Human CRIP2 protein
Conjugation
Unconjugated
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRIP2 (rh CRIP2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human CRIP2 in human placenta with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human CRIP2 in human placenta with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-CRIP2 antibody
CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-kappaB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-kappaB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-kappaB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.
References
Chang DF. et al., 2003, Dev Cell. 4 (1):107-18. Huber A. et al., 2000, J Biol Chem. 275 (8): 5504-11. Karim MA. et al., 1996, Genomics. 31 (2): 167-76.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30,221 Da
NCBI Official Full Name
cysteine-rich protein 2 isoform 2
NCBI Official Synonym Full Names
cysteine-rich protein 2
NCBI Official Symbol
CRIP2
NCBI Official Synonym Symbols
CRIP; CRP2; ESP1
NCBI Protein Information
cysteine-rich protein 2; Cysteine-rich intestinal protein; LIM domain protein ESP1/CRP2
UniProt Protein Name
Cysteine-rich protein 2
Protein Family
UniProt Gene Name
CRIP2
UniProt Synonym Gene Names
CRP2; CRP-2
UniProt Entry Name
CRIP2_HUMAN
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Product Notes
The CRIP2 crip2 (Catalog #AAA8107388) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-CRIP2 Antibody, Mouse Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CRIP2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the CRIP2 crip2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRIP2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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