Mouse anti-Human CRABP1 Monoclonal Antibody | anti-CRABP1 antibody

CRABP1 (Cellular Retinoic Acid-binding Protein 1, Cellular Retinoic Acid-binding Protein I, CRABP-I, RBP5)

Cat. Num. AAA6000868

• Gene Names: CRABP1; RBP5; CRABP; CRABPI; CRABP-I
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CRABP1; Monoclonal Antibody; CRABP1 (Cellular Retinoic Acid-binding Protein 1; Cellular Retinoic Acid-binding Protein I; CRABP-I; RBP5); Anti -CRABP1 (Cellular Retinoic Acid-binding Protein 1; anti-CRABP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Specificity: Recognizes human CRABP1. Species sequence homology: Mouse.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

• Applicable Applications for anti-CRABP1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, ELISA and Immunohistochemistry.; Dilution: Western Blot: 1:500-1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Recombinant corresponding to aa1-137 of human CRABP1, expressed in E.coli.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with antibody followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Human Prostate (formalin-fixed, paraffin-embedded) stained with antibody followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Human Thyroid (formalin-fixed, paraffin-embedded) stained with antibody followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.)

Western Blot (WB)

(Western analysis of mouse eye extract.)

Related Product Information for anti-CRABP1 antibody

CRABP1 (cellular retinoic acid-binding protein 1) is a member of specific carrier proteins for members of the vitamin A family. CRABP1 is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. It is constitutively expressed and is believed to have different functions in the cell than the related CRABP2. Interestingly, Sytenol A bakuchiol has very specific receptor specificity over retinol and has no effect on the RAR-beta and RAR-gamma receptors and down-regulates CRABP1.

Product Categories/Family for anti-CRABP1 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4758052
• NCBI GeneID: 1381
• NCBI Accession #: NP_004369.1
• NCBI GenBank Nucleotide #: NM_004378.2
• UniProt Accession #: P29762; Q6IAY7; Q8WTV5
• Molecular Weight: 15,566 Da
• NCBI Official Full Name: cellular retinoic acid-binding protein 1
• NCBI Official Synonym Full Names: cellular retinoic acid binding protein 1
• NCBI Official Symbol: CRABP1
• NCBI Official Synonym Symbols: RBP5; CRABP; CRABPI; CRABP-I
• NCBI Protein Information: cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I
• UniProt Protein Name: Cellular retinoic acid-binding protein 1
• Protein Family: Cellular retinoic acid-binding protein
• UniProt Gene Name: CRABP1
• UniProt Synonym Gene Names: RBP5; CRABP-I
• UniProt Entry Name: RABP1_HUMAN

NCBI Description

This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

Uniprot Description

CRABP1: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: cytosol

Molecular Function: protein binding; retinoid binding; retinoic acid binding; transporter activity; retinal binding; retinol binding

Biological Process: transport; multicellular organismal development; signal transduction