Mouse anti-Human, Mouse Connexin 36 Monoclonal Antibody

Connexin 36 (CX36)

Cat. Num. AAA603756

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Connexin 36; Monoclonal Antibody; Connexin 36 (CX36); Anti -Connexin 36 (CX36); anti-Connexin 36 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 3G105
• Specificity: Speci c for the mouse ~36kD Connexin36 protein.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-Connexin 36 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.; Dilution: Western Blot: 1-3ug/ml; Immunoprecipitation (Native): 5-10ug/IP reaction; Immunohistochemistry (Frozen): 1-3ug/ml
• Immunogen: Synthetic peptide derived from the C-terminal region of the rat and mouse Connexin36 proteins. This sequence differs from the human Connexin36 sequence by one amino acid.
• Positive Control: Human Connexin36-transfected HeLa cell lysates.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Connexin 36 antibody

Intercellular communication through gap junctions plays an important role in a variety of cellular processes including homeostasis, morphogenesis, cell differentiation, and growth control (1-4). Gap junctions are transmembrane channels that directly link neighboring cells by mediating the exchange of low-molecular weight (< 1200kD) metabolites, ions, and second messengers. Gap junctions are formed by the interaction of hemichannels (connexons) on adjacent cells. Connexons are hexameric assemblies of connexin proteins.

Product Categories/Family for anti-Connexin 36 antibody

Antibodies; Abs to Connexin; Junction Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 38640584
• NCBI Official Full Name: connexin 36

NCBI Description

This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion. [provided by RefSeq, Oct 2012]

Uniprot Description

GJD2: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Delta-type subfamily.

Protein type: Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral; Channel, misc.

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: connexon complex; integral to membrane; plasma membrane

Molecular Function: gap junction channel activity

Biological Process: regulation of action potential; synaptic transmission; visual perception; transmembrane transport