Mouse anti-Human CLEC4D Monoclonal Antibody | anti-CLEC4D antibody

CLEC4D (C-type Lectin Domain Family 4, Member D, C-type Lectin Superfamily Member 8, C-type Lectin-like Receptor 6, CLEC-6, CLECSF8, MCL)

Cat. Num. AAA609773

• Gene Names: CLEC4D; MCL; MPCL; CLEC6; CLEC-6; CLECSF8; MGC40078
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CLEC4D; Monoclonal Antibody; CLEC4D (C-type Lectin Domain Family 4; Member D; C-type Lectin Superfamily Member 8; C-type Lectin-like Receptor 6; CLEC-6; CLECSF8; MCL); Anti -CLEC4D (C-type Lectin Domain Family 4; anti-CLEC4D antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2B
• Clone Number: 10K53
• Specificity: Recognizes human CLEC4D. Species sequence homology: mouse (63%).
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CLEC4D antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry.
• Immunogen: Purified, NS0-derived, recombinant human CLEC4D (aa52-215; Accession #Q8WXI8).
• Hybridoma: Fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, NS0-derived, recombinant human CLEC4D.
• Preparation and Storage: May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.

Related Product Information for anti-CLEC4D antibody

CLEC4D (C-type lectin domain family 4 member D), also known as CLCSF8, CLEC-6, and MCL, is a 30kD type II transmembrane (TM) glycoprotein that belongs to the CLR (C-type Lectin Receptor) family of molecules. It is synthesized as a 215aa protein that contains a 17aa N-terminal cytoplasmic domain, a 21aa TM segment, and a 177aa C-terminal extracellular region. The extracellular region shows a short stalk and a 118aa CRD (carbohydrate recognition domain). The nature of its carbohydrate ligand is unknown. CLEC4D is restricted to monocytes/macrophages and serves as an endocytic receptor. Homodimers and homotrimers form on the cell surface. The human CLEC4D extracellular region shares 63% aa sequence identity with the mouse extracellular region.

Product Categories/Family for anti-CLEC4D antibody

Antibodies; Abs to Lectins

NCBI and Uniprot Product Information

• NCBI GI #: 31542313
• NCBI GeneID: 338339
• NCBI Accession #: NP_525126.2
• NCBI GenBank Nucleotide #: NM_080387.4
• UniProt Accession #: Q8WXI8; Q8N5J5
• Molecular Weight: 24,704 Da
• NCBI Official Full Name: C-type lectin domain family 4 member D
• NCBI Official Synonym Full Names: C-type lectin domain family 4, member D
• NCBI Official Symbol: CLEC4D
• NCBI Official Synonym Symbols: MCL; MPCL; CLEC6; CLEC-6; CLECSF8; MGC40078
• NCBI Protein Information: C-type lectin domain family 4 member D; OTTHUMP00000239173; OTTHUMP00000239174; C-type lectin receptor; macrophage C-type lectin; C-type lectin-like receptor 6; C-type lectin superfamily member 8; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8
• UniProt Protein Name: C-type lectin domain family 4 member D
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC4D
• UniProt Synonym Gene Names: CLECSF8; MCL
• UniProt Entry Name: CLC4D_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]

Uniprot Description

CLEC4D: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane

Molecular Function: carbohydrate binding

Biological Process: innate immune response