Rabbit anti-Human CLEC1B  Monoclonal Antibody | anti-CLEC1B  antibody

Rabbit anti Human CLEC1B  Monoclonal Antibody

Cat. Num. AAA2544129

• Gene Names: CLEC1B; CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
• Reactivity: Human
• Applications: ELISA
• Synonyms: CLEC1B ; Monoclonal Antibody; Rabbit anti Human CLEC1B Monoclonal Antibody; anti-CLEC1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 196

• Applicable Applications for anti-CLEC1B antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CLEC1B. The detection limit for Human CLEC1B is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human CLEC1B/CLEC2 Protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human CLEC1B/CLEC2 (rh CLEC1B/CLEC2; Gln 58-Pro 229; NP_057593.3).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CLEC1B  antibody

CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

NCBI and Uniprot Product Information

• NCBI GI #: 153252048
• NCBI GeneID: 51266
• NCBI GenBank Nucleotide #: NM_001099431.1
• Molecular Weight: 23,096 Da
• NCBI Official Full Name: C-type lectin domain family 1 member B isoform b
• NCBI Official Synonym Full Names: C-type lectin domain family 1 member B
• NCBI Official Symbol: CLEC1B
• NCBI Official Synonym Symbols: CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik
• NCBI Protein Information: C-type lectin domain family 1 member B
• UniProt Protein Name: C-type lectin domain family 1 member B
• UniProt Gene Name: CLEC1B
• UniProt Synonym Gene Names: CLEC2; CLEC-2
• UniProt Entry Name: CLC1B_HUMAN

NCBI Description

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

Uniprot Description

CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response; platelet activation