Mouse cdk5, p31 Monoclonal Antibody
cdk5, p31 (Cyclin-dependent Kinase 5)
Reactivity
C elegans, Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunoprecipitation, Immunofluorescence
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
cdk5; p31; Monoclonal Antibody; p31 (Cyclin-dependent Kinase 5); Anti -cdk5; anti-cdk5; p31 antibody
Host
Mouse
Reactivity
C elegans, Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
5J211
Specificity
Recognizes human cdk5 at ~31kD. Species Crossreactivity: Rat, mouse and C. elegans.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
Applicable Applications for anti-cdk5, p31 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Application Notes
Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunofluorescence.
Dilution: Western Blot: 0.5-1ug/ml
Immunoprecipitation: 1-2ug per 200-500ug of protein lysate.
Optimal dilutions to be determined by researcher.
Dilution: Western Blot: 0.5-1ug/ml
Immunoprecipitation: 1-2ug per 200-500ug of protein lysate.
Optimal dilutions to be determined by researcher.
Immunogen
Recombinant cdk5 protein.
Hybridoma
Produced by the fusion between BALB/c splenocytes and mouse myeloma NS1 cells.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-cdk5, p31 antibody
Cdk5 is expressed in both cycling and non-cycling cells and is present in numerous mammalian tissues. However, its highest concentration is found in differentiated neurons, and the only known protein that activates cdk5, p35Nck5a, is expressed solely in the brain. The mechanism of activation of cdk5 by p35Nck5a differs from that of cyclin activation of cdks in that full cdk5 kinase activity is achieved in the absence of phosphorylation of cdk5. Cdk5 activity is reported to be involved in terminal differentiation of neurons and active cdk5 is thought to be involved in the in vivo phosphorylation of the neurofilament proteins and tau which are hyperphosphorylated in neurodegenerative diseases such as Alzheimer's disease.
Product Categories/Family for anti-cdk5, p31 antibody
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Product Notes
The cdk5, p31 (Catalog #AAA603104) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The cdk5, p31 (Cyclin-dependent Kinase 5) reacts with C elegans, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's cdk5, p31 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF). Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunofluorescence. Dilution: Western Blot: 0.5-1ug/ml Immunoprecipitation: 1-2ug per 200-500ug of protein lysate. Optimal dilutions to be determined by researcher. Researchers should empirically determine the suitability of the cdk5, p31 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "cdk5, p31, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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