Mouse anti-Human CD96 Monoclonal Antibody | anti-CD96 antibody

CD96 (CD96 Antigen, DKFZp667E2122, MGC22596, TACTILE, T cell-activated increased late expression protein, T-cell surface protein tactile precursor)

Cat. Num. AAA605801

• Gene Names: CD96; TACTILE; MGC22596; DKFZp667E2122
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Purified by protein G affinity chromatography
• Synonyms: CD96; Monoclonal Antibody; CD96 (CD96 Antigen; DKFZp667E2122; MGC22596; TACTILE; T cell-activated increased late expression protein; T-cell surface protein tactile precursor); Anti -CD96 (CD96 Antigen; anti-CD96 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 9G159
• Specificity: Recognizes human CD96, also known as T cell-activated increased late expression (Tactile). Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.
• Purity/Purification: Purified by protein G affinity chromatography
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA.
• Concentration: 0.1mg/ml (varies by lot)

• Applicable Applications for anti-CD96 antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry and Funcional Studies. Blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.; Dilution: Flow Cytometry: 1:50; Functional Studies: Make according to the amounts of CD96 to be inactivated. Optimal dilutions to be determined by the researcher.
• Immunogen: Human NK92 cells
• Grade: Affinity Purified
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeatedd freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CD96 antibody

CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR or CD155). Furthermore CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. This means NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cells adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.

Product Categories/Family for anti-CD96 antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 119600104
• NCBI GeneID: 10225
• UniProt Accession #: P40200; Q5JPB3; Q8WUE2
• NCBI Official Full Name: CD96 antigen, isoform CRA_c
• NCBI Official Synonym Full Names: CD96 molecule
• NCBI Official Symbol: CD96
• NCBI Official Synonym Symbols: TACTILE; MGC22596; DKFZp667E2122
• NCBI Protein Information: T-cell surface protein tactile; CD96 antigen; OTTHUMP00000214642; OTTHUMP00000214643; OTTHUMP00000214645; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein
• UniProt Protein Name: T-cell surface protein tactile
• Protein Family: T-cell surface protein tactile
• UniProt Gene Name: CD96
• UniProt Entry Name: TACT_HUMAN

NCBI Description

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Uniprot Description

CD96: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Defects in CD96 are a cause of C syndrome (CSYN); also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.13-q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: regulation of immune response; immune response; cell adhesion

Disease: C Syndrome