Mouse anti-Rat CD86 Monoclonal Antibody | anti-CD86 antibody

Anti-CD86 Antibody, Mouse Monoclonal

Cat. Num. AAA8112641

• Gene Names: Cd86; B7-2
• Reactivity: Rat
• Applications: ELISA
• Purity: Protein A
• Synonyms: CD86; Monoclonal Antibody; Anti-CD86 Antibody; Mouse Monoclonal; CD86/B7-2 Antibody; Mouse MAb; CD86 antigen; anti-CD86 antibody

• Host: Mouse
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: Mouse IgG2a
• Clone Number: 6B4A7
• Specificity: Rat CD86/B7-2.; No cross-reactivity in ELISA with Human B7-1, Human B7-2, Mouse B7-2, Mouse CD274, Human TNFRI , Human TNFRII, Human cell lysate (293 cell line)
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CD86 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Rat CD86/B7-2 protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD86/B7-2 (rR CD86/B7-2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD86 antibody

CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.

Product Categories/Family for anti-CD86 antibody

Cancer Drug Targets

References

Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.Rau FC, et al. (2009) B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol. 183(12): 7661-71.Dai ZS, et al. (2009) Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia. Int J Hematol. 89(5): 656-63.

NCBI and Uniprot Product Information

• NCBI GI #: 11464989
• NCBI GeneID: 56822
• NCBI Accession #: NP_064466.1
• NCBI GenBank Nucleotide #: NM_020081.1
• UniProt Accession #: O35531; F1LNG0
• Molecular Weight: 35,574 Da
• NCBI Official Full Name: T-lymphocyte activation antigen CD86
• NCBI Official Synonym Full Names: CD86 molecule
• NCBI Official Symbol: Cd86
• NCBI Official Synonym Symbols: B7-2
• NCBI Protein Information: T-lymphocyte activation antigen CD86
• UniProt Protein Name: CD86 molecule
• Protein Family: T-lymphocyte activation antigen
• UniProt Gene Name: Cd86

NCBI Description

plays a role in T-cell activation and proliferation [RGD, Feb 2006]