Testing Data
(1,3 105 Raji cells were lysed (lysis buffer containing 1% Brij97 or triton)
Migration SDS/page 5-15% gel under non-reducing conditions)
Mouse anti-Human CD81 Monoclonal Antibody | anti-CD81 antibody
Mouse Anti-Human CD81 Monoclonal Antibody, Azide Free Clone TS81
Testing Data
(1,3 105 Raji cells were lysed (lysis buffer containing 1% Brij97 or triton) Migration SDS/page 5-15% gel under non-reducing conditions)
Testing Data
(1,3 105 Raji cells were lysed (lysis buffer containing 1% Brij97 or triton)
Migration SDS/page 5-15% gel under non-reducing conditions)
• Charrin et.al Eur J Immunol 2003
• Charrin et.al. Biochem J 2003
• Charrin et.al FEBS lett 2002
• Charrin et.al. J Biol Chem 2001
• Serman et.al Nucleic Acids Res 2007
• Silvie et.al J Cell Sci 2006
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
Subunit structure: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11. Ref.6 Ref.8 Ref.9 Ref.10 Ref.11 Ref.14
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
Post-translational modification: Not glycosylated
Probable.
Involvement in disease: Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12
Sequence similarities: Belongs to the tetraspanin (TM4SF) family.
Research Articles on CD81
Similar Products
Product Notes
The CD81 cd81 (Catalog #AAA335654) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD81 Monoclonal Antibody, Azide Free Clone TS81 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD81 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the CD81 cd81 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD81, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
