Mouse CD58 Biotin Monoclonal Antibody | anti-CD58 antibody

Mouse Anti Human CD58 Biotin

Cat. Num. AAA140149

• Gene Names: CD58; ag3; LFA3; LFA-3
• Purity: Ion-Exchange Column Protein concentration1mg/ml in PBS (after reconstitution).
• Synonyms: CD58 Biotin; Monoclonal Antibody; Mouse Anti Human CD58 Biotin; CD58 Antibody; Biotin; CD58; Mouse Anti-Human; LFA-3; Ag3; Surface glycoprotein LFA-3; anti-CD58 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: hCD58
• Purity/Purification: Ion-Exchange Column Protein concentration1mg/ml in PBS (after reconstitution).
• Sequence Length: 248

• Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Immunogen: Human Erythrocytes.
• Antibody Properties: Staining antibody. For staining, use 10 ul/1,000,000 cells.
• Available Conjugates: This antibody is also available unconjugated to and conjugated to FITC. For staining with biotin or FITC-conjugated antibody use 5-10 ul/1,000,000 cells.
• Preparation and Storage: Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.

Related Product Information for anti-CD58 antibody

Introduction: CD58 is part of the immunoglobulin superfamily. CD58 is a ligand of the T lymphocyte CD2 protein, and is invloved in adhesion and activation of T lymphocytes. CD58 is localized to the plasma membrane.

Product Categories/Family for anti-CD58 antibody

Monoclonal Antibodies; Anti-Human LYMPHOCYTES; Monoclonal Antibodies; Anti Human Lymphocyte

NCBI and Uniprot Product Information

• NCBI GI #: 221316575
• NCBI GeneID: 965
• NCBI Accession #: NP_001138294.1
• NCBI GenBank Nucleotide #: NM_001144822.1
• Molecular Weight: 27,960 Da
• NCBI Official Full Name: lymphocyte function-associated antigen 3 isoform 2
• NCBI Official Synonym Full Names: CD58 molecule
• NCBI Official Symbol: CD58
• NCBI Official Synonym Symbols: ag3; LFA3; LFA-3
• NCBI Protein Information: lymphocyte function-associated antigen 3; CD58 antigen, (lymphocyte function-associated antigen 3); surface glycoprotein LFA-3
• UniProt Protein Name: Lymphocyte function-associated antigen 3
• Protein Family: Lymphocyte function-associated antigen
• UniProt Gene Name: CD58
• UniProt Synonym Gene Names: LFA3; Ag3
• UniProt Entry Name: LFA3_HUMAN

NCBI Description

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Uniprot Description

CD58: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell adhesion; blood coagulation; leukocyte migration