Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Mouse CD5 Monoclonal Antibody | anti-CD5 antibody
CD5 Monoclonal Antibody
IF: 1:50-200
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Rat kidney tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Rat kidney tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse heart tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
Immunofluorescence (IF)
(Immunofluorescence analysis of Mouse heart tissue using CD5 Monoclonal Antibody at dilution of 1:200.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Uniprot Description
CD5: a protein that in lymphocytes is involved in host defences and immune responses. Expressed in T cells, B cells, and chronic lymphocytic leukemia B cells (BCLL). Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. B cells and T cells express a full length isoform expressed on the plasma membrane, while B cells also express a truncated intracellular isoform. B cells expressing the integral membrane isoform are CD5+ by FACS analysis, while those expressing only the cytoplasmic isoform are CD5-. Expression of either isoform mediates the activation of STAT3 and NFAT2 in CLL B and the resultant constitutive production of IL-10, a B cell growth factor. Contains 3 SRCR domains. Two alternatively human isoforms have been reported.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: external side of plasma membrane; integral component of plasma membrane; plasma membrane
Molecular Function: protein binding; receptor activity; scavenger receptor activity; transmembrane receptor activity
Biological Process: cell proliferation; cell recognition; receptor-mediated endocytosis; T cell costimulation
Research Articles on CD5
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Product Notes
The CD5 cd5 (Catalog #AAA2548879) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD5 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF). IHC: 1:100-1:300 IF: 1:50-200. Researchers should empirically determine the suitability of the CD5 cd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD5, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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