Rabbit anti-Human CD1a Monoclonal Antibody | anti-CD1a antibody

Anti - CD1a

Cat. Num. AAA684070

• Gene Names: CD1A; R4; T6; CD1; FCB6; HTA1
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: CD1a; Monoclonal Antibody; Anti - CD1a; anti-CD1a antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: L21-A
• Specificity: Human
• Sequence Length: 327

• Applicable Applications for anti-CD1a antibody: Immunohistochemistry (IHC) - Formalin/Paraffin
• Application Notes: IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user
• Immunogen: Peptide derived from C-terminal region, near the transmembrane domain of human CD1-a
• Storage Buffer: 20 mM Tris-HCI, pH 8.0
• Stabilizer: 20 mg/ml BSA
• Preservative: 0.05% NaN3
• Preparation and Storage: Store at +4 degree C.

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 288558852
• NCBI GeneID: 909
• UniProt Accession #: P06126; Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5; D3DVD7
• Molecular Weight: 37,077 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD1a
• NCBI Official Synonym Full Names: CD1a molecule
• NCBI Official Symbol: CD1A
• NCBI Official Synonym Symbols: R4; T6; CD1; FCB6; HTA1
• NCBI Protein Information: T-cell surface glycoprotein CD1a; hTa1 thymocyte antigen; CD1A antigen, a polypeptide; cluster of differentiation 1 A; T-cell surface antigen T6/Leu-6; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a
• UniProt Protein Name: T-cell surface glycoprotein CD1a
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD1A
• UniProt Synonym Gene Names: hTa1 thymocyte antigen
• UniProt Entry Name: CD1A_HUMAN

NCBI Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Ref.10 Ref.11 Ref.12

Subunit structure: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74. Ref.12

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts. Ref.10 Ref.12 Ref.15

Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. Ref.10 Ref.12

Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.