Mouse anti-Human CD106 Monoclonal Antibody | anti-CD106 antibody

Mouse anti Human CD106

Cat. Num. AAA570328

• Gene Names: VCAM1; CD106; INCAM-100
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Synonyms: CD106; Monoclonal Antibody; Mouse anti Human CD106; anti-CD106 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: B-K9
• Specificity: The mouse monoclonal antibody B-K9 recognizes human CD106.
• Form/Format: Each vial contains 100ul 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
• Sequence Length: 739

• Applicable Applications for anti-CD106 antibody: Flow Cytometry (FC/FACS)
• Application Notes: The antibody produced by clone B-K9 can be used for CD106 cell identification, quantification and isolation by flow cytometry.; ; The antibody has also been reported for use in blocking studies. For this application, please request a sodium azide free antibody format.; ; Optimal antibody dilutions for the different applications should be determined by titration. The recommended range for flow cytometry is 1:100 - 1:200.
• Source Note: B-K9 is a mouse monoclonal IgG1 antibody derived by fusion of X63/Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with activated human umbilical vein endothelial cells.
• Preparation and Storage: Store at 4 degree C, or in small aliquots at -20 degree C.

Related Product Information for anti-CD106 antibody

CD106 is a 110kDa type 1 transmembrane sialoglycoprotein, which is also known as vascular cell adhesion molecule 1 (VCAM-1). The CD106 protein is primarily expressed on activated vascular endothelium but has also been detected on dendritic cell types, macrophages and non-vascular cells in certain tissues. Expression of CD106 is induced by inflammatory stimuli and cytokines. CD106 binds to the integrins CD49d/CD29 (also known as VLA4) and alpha4beta7 and is important in leucocyte-endothelial cell adhesion and signal transduction. The CD106 protein is thought to play a key role in the migration of leucocyte from the blood into tissues, particularly at sites of inflammation. Studies suggest that CD106 may also play a role in the development of rheumatoid arthritis and atherosclerosis.

Product Categories/Family for anti-CD106 antibody

Immunology; Cell Adhesion

References

1) Wagner BJ, Lob S, Lindau D, Horzer H, Guckel B, Klein G, Glatzle J, Rammensee HG, Brucher BL, Konigsrainer A. Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and B1 integrin. Int. J. Oncol. 2011;39(6):1593 - 1600.
2) Ticchioni M, Raimondi V, Lamy L, Wijdenes J, Lindberg FP, Brown EJ, Bernard A. Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow. FASEB J. 2001; 15:341-350

NCBI and Uniprot Product Information

• NCBI GI #: 4507875
• NCBI GeneID: 7412
• NCBI Accession #: NP_001069.1
• NCBI GenBank Nucleotide #: NM_001078.3
• UniProt Accession #: P19320; Q6NUP8; A8K6R7; B4DKS4; E9PDD1
• Molecular Weight: 74,346 Da
• NCBI Official Full Name: vascular cell adhesion protein 1 isoform a
• NCBI Official Synonym Full Names: vascular cell adhesion molecule 1
• NCBI Official Symbol: VCAM1
• NCBI Official Synonym Symbols: CD106; INCAM-100
• NCBI Protein Information: vascular cell adhesion protein 1; CD106 antigen
• UniProt Protein Name: Vascular cell adhesion protein 1
• UniProt Gene Name: VCAM1
• UniProt Synonym Gene Names: L1CAM; V-CAM 1; VCAM-1
• UniProt Entry Name: VCAM1_HUMAN

NCBI Description

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium

Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding

Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging