Testing Data
(KM-H2 cells stained with Mouse anti Human CD106)
Mouse CD106 Monoclonal Antibody | anti-CD106 antibody
MOUSE ANTI HUMAN CD106
Purified IgG - liquid
Functional Assays: Application Note: This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays.
Western Blotting: Application Note: This product has been reported to work in non-reducing conditions
Preparation
Shelf Life: 18 months from date of despatch.
Testing Data
(KM-H2 cells stained with Mouse anti Human CD106)
Testing Data
(KM-H2 cells stained with Mouse anti Human CD106)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; apical part of cell; endoplasmic reticulum; early endosome; integral to membrane; plasma membrane; podosome; sarcolemma; filopodium; external side of plasma membrane
Molecular Function: amine oxidase activity; integrin binding; cell adhesion molecule binding
Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; heart development; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; amine metabolic process; response to ionizing radiation; leukocyte tethering or rolling; cell adhesion; acute inflammatory response; response to nutrient; aging
Research Articles on CD106
Similar Products
Product Notes
The CD106 vcam1 (Catalog #AAA213194) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MOUSE ANTI HUMAN CD106 reacts with Pig, Rhesus Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's CD106 can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Functional Assays (FN)*, Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)*. Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Functional Assays: Application Note: This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. Western Blotting: Application Note: This product has been reported to work in non-reducing conditions. Researchers should empirically determine the suitability of the CD106 vcam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD106, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
