Goat FASN / Fatty Acid Synthase Polyclonal Antibody | anti-FASN antibody

Goat Polyclonal to Human FASN / Fatty Acid Synthase

Cat. Num. AAA246726

• Gene Names: FASN; FAS; OA-519; SDR27X1
• Reactivity: Gorilla, Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: FASN / Fatty Acid Synthase; Polyclonal Antibody; Goat Polyclonal to Human FASN / Fatty Acid Synthase; Anti-FASN / Fatty Acid Synthase Antibody (Internal) IHC-plus; FASN; Fatty acid synthase; OA-519; SDR27X1; Human FASN; Fatty Acid Synthase; anti-FASN antibody

• Host: Goat
• Reactivity: Gorilla, Human
• Clonality: Polyclonal
• Specificity: Human FASN / Fatty Acid Synthase.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 2511

• Applicable Applications for anti-FASN antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide YRDRDSQRDLVE from internal region of human FASN (NP_004095.4). Percent identity by BLAST analysis: Human, Gorilla (100%); Coccidioides (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: FASN / Fatty Acid Synthase antibody was raised against synthetic peptide YRDRDSQRDLVE from internal region of human FASN (NP_004095.4). Percent identity by BLAST analysis: Human, Gorilla (100%); Coccidioides (83%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-Fatty Acid Synthase antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-Fatty Acid Synthase antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 41872631
• NCBI GeneID: 2194
• NCBI Accession #: NP_004095.4
• NCBI GenBank Nucleotide #: NM_004104.4
• UniProt Accession #: P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0
• Molecular Weight: 273,427 Da
• NCBI Official Full Name: fatty acid synthase
• NCBI Official Synonym Full Names: fatty acid synthase
• NCBI Official Symbol: FASN
• NCBI Official Synonym Symbols: FAS; OA-519; SDR27X1
• NCBI Protein Information: fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1
• UniProt Protein Name: Fatty acid synthase
• Protein Family: Fatty acid synthase
• UniProt Gene Name: FASN
• UniProt Synonym Gene Names: FAS
• UniProt Entry Name: FAS_HUMAN

NCBI Description

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Uniprot Description

FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Protein type: Acetyltransferase; Oxidoreductase; EC 4.2.1.59; Lyase; EC 2.3.1.39; Lipid Metabolism - fatty acid biosynthesis; EC 1.1.1.100; EC 3.1.2.14; Hydrolase; EC 2.3.1.41; EC 2.3.1.85; EC 1.3.1.39; EC 2.3.1.38

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: Golgi apparatus; mitochondrion; glycogen granule; membrane; cytoplasm; melanosome; plasma membrane; cytosol

Molecular Function: protein homodimerization activity; fatty-acid synthase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; [acyl-carrier-protein] S-acetyltransferase activity; drug binding; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity

Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process