Rabbit RBBP6 Polyclonal Antibody | anti-RBBP6 antibody

RBBP6 Polyclonal Antibody

Cat. Num. AAA3006477

• Gene Names: RBBP6; PACT; MY038; P2P-R; RBQ-1; SNAMA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: RBBP6; Polyclonal Antibody; RBBP6 Polyclonal Antibody; E3 ubiquitin-protein ligase RBBP6; EC=6.3.2.-; Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis; P2PR; PACT; RBQ1; My038; anti-RBBP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: RBBP6 polyclonal antibody detects endogenous levels of RBBP6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1792

• Applicable Applications for anti-RBBP6 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human RBBP6.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of RBBP6 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-RBBP6 antibody

Rb protein and p53 are both cell cycle checkpoint components. Evidence suggests that p53 plays a role in regulating the phosphorylation of Rb by inducing p21 transcription, thus preventing Rb phosphorylation at the G1 to S transition. Protein-protein interactions seem to be central in p53 cellular activities, as previously demonstrated with MDM2 and SV40 large T antigen. Two novel proteins have been identified by their abilities to bind to p53 and/ or Rb. Human RBQ-1 (also designated RBBP6) has been cloned as a novel protein that binds to the retinoblastoma (Rb) gene product. A related mouse protein, P2P-R, also designated PACT (for p53 associated cellular protein-testis derived), has been shown to bind to both Rb and p53. Recombinant P2P-R binds to wildtype p53 but not to mutant p53, and it can interfere with p53 specific DNA binding. RBQ-1 may be a truncated human form of the P2P-R protein.

NCBI and Uniprot Product Information

• NCBI GI #: 74762440
• NCBI GeneID: 5930
• UniProt Accession #: Q7Z6E9
• Molecular Weight: ~ 13kDa
• NCBI Official Full Name: E3 ubiquitin-protein ligase RBBP6
• NCBI Official Synonym Full Names: RB binding protein 6, ubiquitin ligase
• NCBI Official Symbol: RBBP6
• NCBI Official Synonym Symbols: PACT; MY038; P2P-R; RBQ-1; SNAMA
• NCBI Protein Information: E3 ubiquitin-protein ligase RBBP6
• UniProt Protein Name: E3 ubiquitin-protein ligase RBBP6
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RBBP6
• UniProt Synonym Gene Names: P2PR; PACT; RBQ1
• UniProt Entry Name: RBBP6_HUMAN

NCBI Description

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]