Mouse Cav1.3 Monoclonal Antibody | anti-cacna1d antibody

Cav1.3 (Alpha 1d, L-type of Voltage-gated Calcium Channel, Cacna1d)

Cat. Num. AAA608747

• Gene Names: cacna1d; cav1.3; ca(v)1.3
• Reactivity: Human, Rat, Sheep
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Cav1.3; Monoclonal Antibody; Cav1.3 (Alpha 1d; L-type of Voltage-gated Calcium Channel; Cacna1d); Anti -Cav1.3 (Alpha 1d; anti-cacna1d antibody

• Host: Mouse
• Reactivity: Human, Rat, Sheep
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10F689
• Specificity: Recognizes rat calcium channel. Species Crossreactivity: human.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.

• Applicable Applications for anti-cacna1d antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.; Dilution: Immunofluorescence:1-10ug/ml; Western Blot:1-10ug/ml; Immunohistochemistry:0.1-1ug/ml; Immunocytochemistry:0.1-1ug/ml
• Immunogen: Fusion protein aa2025-2161 (C Terminal) of rat Cav1.3 (also known as voltage dependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-cacna1d antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological

There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels.
Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. Cav1.3 subunits are primarily expressed in neurons and neuroendocine cells. Some studies suggest however that Cav1.3 is also found in the atria, and may figure prominently in atrial arrhythmias (3). Cav1.3 also carries the primary sensory receptors of the mammalian cochlea, and are also expressed in the electromotile outer hair cells (4).

Product Categories/Family for anti-cacna1d antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 118404096
• NCBI GeneID: 780391
• NCBI Accession #: NP_001072929.1
• NCBI GenBank Nucleotide #: NM_001079461.1
• NCBI Official Full Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
• NCBI Official Synonym Full Names: calcium channel, voltage-dependent, L type, alpha 1D subunit
• NCBI Official Symbol: cacna1d
• NCBI Official Synonym Symbols: cav1.3; ca(v)1.3
• NCBI Protein Information: calcium channel, voltage-dependent, L type, alpha 1D subunit
• Protein Family: Voltage-dependent L-type calcium channel