Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Mouse anti-Human Caspase and RIP Adapter with Death Domain Monoclonal Antibody | anti-CRADD antibody

Mouse Anti Human Caspase and RIP Adapter with Death Domain

Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified from mouse ascitic fluids by protein-A affinity chromatography
Synonyms
Caspase and RIP Adapter with Death Domain; Monoclonal Antibody; Mouse Anti Human Caspase and RIP Adapter with Death Domain; CRADD Antibody; Mouse Anti Human; RAIDD; MGC9163; CRADD; Death domain-containing protein CRADD; Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CASP2 and RIPK1 domain containing adaptor with death domain; anti-CRADD antibody
Ordering
 
When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures.
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone Number
PAT14G8AT
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Form/Format
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
Sequence Length
199
Applicable Applications for anti-CRADD antibody
ELISA (EIA), Western Blot (WB)
Application Notes
CRADD antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.
Ig Subclass
Mouse IgG1 heavy chain and k light chain.
Immunogen
Anti-human CRADD mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CRADD protein 1-199 amino acids purified from E Coli.
Preparation and Storage
Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Related Product Information for anti-CRADD antibody
CRADD is a 22kDa, widely-expressed cytosolic adaptor/signaling protein that induces cell apoptosis/cell death in numerous tissues. CRADD is a death domain (CARD) that recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes TNFR1A, RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Product Categories/Family for anti-CRADD antibody

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
Molecular Weight
11,826 Da
NCBI Official Full Name
Caspase and RIP adapter
UniProt Protein Name
Death domain-containing protein CRADD
UniProt Gene Name
CRADD
UniProt Synonym Gene Names
RAIDD
UniProt Entry Name
CRADD_HUMAN

Uniprot Description

CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 12q21.33-q23.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protease binding; protein binding; protein binding, bridging

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; induction of apoptosis via death domain receptors; regulation of apoptosis

Disease: Mental Retardation, Autosomal Recessive 34

Similar Products

Product Notes

The CRADD cradd (Catalog #AAA140534) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human Caspase and RIP Adapter with Death Domain reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Caspase and RIP Adapter with Death Domain can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). CRADD antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Researchers should empirically determine the suitability of the CRADD cradd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase and RIP Adapter with Death Domain, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
Looking for a specific manual?
Request a Manual