Related Product Information for anti-CRADD antibody
CRADD is a 22kDa, widely-expressed cytosolic adaptor/signaling protein that induces cell apoptosis/cell death in numerous tissues. CRADD is a death domain (CARD) that recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes TNFR1A, RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Product Categories/Family for anti-CRADD antibody
Uniprot Description
CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 12q21.33-q23.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protease binding; protein binding; protein binding, bridging
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; induction of apoptosis via death domain receptors; regulation of apoptosis
Disease: Mental Retardation, Autosomal Recessive 34
Product Notes
The CRADD cradd (Catalog #
AAA140534) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human Caspase and RIP Adapter with Death Domain reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Caspase and RIP Adapter with Death Domain can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). CRADD antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Researchers should empirically determine the suitability of the CRADD cradd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"Caspase and RIP Adapter with Death Domain, Monoclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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