Mouse anti-Human, Mouse Calumenin Monoclonal Antibody | anti-CALU antibody

Calumenin Antibody

Cat. Num. AAA9215403

• Reactivity: Human, Mouse
• Applications: Western Blot
• Synonyms: Calumenin; Monoclonal Antibody; Calumenin Antibody; Purified Mouse Monoclonal Antibody (Mab); CALU; CALU_HUMAN; Calumenin 1; Calumenin 2; Crocalbin; crocalbin-like protein; FLJ90608; IEF SSP 9302; multiple EF-hand protein; OTTHUMP00000212712; OTTHUMP00000212713; OTTHUMP00000212714; OTTHUMP00000212715.; anti-CALU antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Form/Format: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
• Sequence Length: 315

• Applicable Applications for anti-CALU antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of Calumenin in SW480,mouse intestine and A431 cell lysates and using Calumenin mouse mAb (1:1000 diluted).Predicted band size: 37KDa.Observed band size:45KDa.)

Related Product Information for anti-CALU antibody

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Product Categories/Family for anti-CALU antibody

Signal Transduction

References

Vorum H.,et al.Biochim. Biophys. Acta 1386:121-131(1998). Yabe D.,et al.Genomics 49:331-333(1998). Peterson R.E. Jr.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. Wang Q.,et al.Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 194578885
• NCBI GeneID: 813
• NCBI Accession #: NP_001124146.1
• NCBI GenBank Nucleotide #: NM_001130674.2
• UniProt Accession #: O43852; B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57
• Molecular Weight: 37107
• NCBI Official Full Name: calumenin isoform b
• NCBI Official Synonym Full Names: calumenin
• NCBI Official Symbol: CALU
• NCBI Protein Information: calumenin
• UniProt Protein Name: Calumenin
• Protein Family: Calumenin
• UniProt Gene Name: CALU
• UniProt Entry Name: CALU_HUMAN

NCBI Description

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Uniprot Description

CALU: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Calcium-binding

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: Golgi apparatus; sarcoplasmic reticulum lumen; membrane; endoplasmic reticulum; extracellular region; melanosome

Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding; calcium ion binding

Biological Process: platelet activation; platelet degranulation; negative regulation of catalytic activity; blood coagulation; axon regeneration in the peripheral nervous system; response to organic cyclic substance